Dynamic Kinetic Asymmetric Domino Oxa-Michael/Carbocyclization by Combination of Transition-Metal and Amine Catalysis: Catalytic Enantioselective Synthesis of Dihydrofurans
2010 (English)In: Chemistry - A European Journal, ISSN 0947-6539, E-ISSN 1521-3765, Vol. 16, no 47, 13930-13934 p.Article in journal (Refereed) Published
A one-pot highly chemo- and enantioselective catalytic domino oxa-Michael/carbocyclization between α,β-unsaturated aldehydes and propargylic alcohols is presented. This dynamic kinetic transformation requires a combination of transition-metal and amine catalysis to afford functionalized dihydrofurans in good to high yields and up to 99.5:0.5 e.r.
Place, publisher, year, edition, pages
2010. Vol. 16, no 47, 13930-13934 p.
asymmetric catalysis, co-catalysis, domino reactions, furans, palladium
IdentifiersURN: urn:nbn:se:kth:diva-30558DOI: 10.1002/chem.201001992ISI: 000286289700006ScopusID: 2-s2.0-78650292001OAI: oai:DiVA.org:kth-30558DiVA: diva2:401133
FunderSwedish Research Council
QC 201103012011-03-012011-02-282011-03-01Bibliographically approved