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Numerical simulation of the failure of ventricular tissue due to deep penetration: The impact of constitutive properties
KTH, School of Engineering Sciences (SCI), Solid Mechanics (Dept.), Biomechanics.
KTH, School of Engineering Sciences (SCI), Solid Mechanics (Dept.), Biomechanics.
2011 (English)In: Journal of Biomechanics, ISSN 0021-9290, E-ISSN 1873-2380, Vol. 44, no 1, 45-51 p.Article in journal (Refereed) Published
Abstract [en]

Lead perforation is a rare but serious clinical complication of pacemaker implantation, and towards understanding this malfunction, the present study investigated myocardial failure due to deep penetration by an advancing rigid punch. To this end, a non-linear Finite Element model was developed that integrates constitutive data published in the literature with information from in vitro tensile testing in cross-fibre direction of porcine myocardial tissue. The Finite Element model considered non-linear, isotropic and visco-elastic properties of the myocardium, and tissue failure was phenomenologically described by a Traction Separation Law. In vitro penetration testing of porcine myocardium was used to validate the Finite Element model, and a particular objective of the study was to investigate the impact of different constitutive parameters on the simulated results. Specifically, results demonstrated that visco-elastic properties of the tissue strongly determine the failure process, whereas dissipative effects directly related to failure had a minor impact on the simulation results. In addition, non-linearity of the bulk material did not change the predicted peak penetration force and the simulations did not reveal elastic crack-tip blunting. The performed study provided novel insights into ventricular failure due to deep penetration, and provided useful information with which to develop numerical failure models.

Place, publisher, year, edition, pages
2011. Vol. 44, no 1, 45-51 p.
Keyword [en]
Myocardium, Fracture, Penetration failure, Soft biological tissue, Pacemaker lead perforation, Constitutive properties, FEM, Cohesive zone, Fracture process zone, Visco-elastic, Non-linear
National Category
Other Engineering and Technologies not elsewhere specified
Identifiers
URN: urn:nbn:se:kth:diva-30529DOI: 10.1016/j.jbiomech.2010.08.022ISI: 000286550500008Scopus ID: 2-s2.0-78650014072OAI: oai:DiVA.org:kth-30529DiVA: diva2:401816
Funder
Swedish Research Council, 2007-4514
Note
QC 20110304Available from: 2011-03-04 Created: 2011-02-28 Last updated: 2017-12-11Bibliographically approved
In thesis
1. Numerical simulation of failure response of vascular tissue due to deep penetration
Open this publication in new window or tab >>Numerical simulation of failure response of vascular tissue due to deep penetration
2011 (English)Licentiate thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Stockholm: KTH Royal Institute of Technology, 2011. xiv p.
Series
Trita-HFL. Report / Royal Institute of Technology, Solid Mechanics, ISSN 1654-1472 ; 0500
National Category
Engineering and Technology
Identifiers
urn:nbn:se:kth:diva-30875 (URN)
Presentation
2011-03-04, Sal E3, KTH, Osquars backe 14, Stockholm, 10:15
Opponent
Supervisors
Note

QC 20110307

Available from: 2011-03-07 Created: 2011-03-07 Last updated: 2013-01-15Bibliographically approved
2. Failure of vascular tissue with applications to the aneurysm wall, carotid plaque and myocardial tissue
Open this publication in new window or tab >>Failure of vascular tissue with applications to the aneurysm wall, carotid plaque and myocardial tissue
2013 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Cardiovascular disease is the leading cause of death in the modern world. Examples are thoracic aortic aneurysm (TAA), abdominal aortic aneurysm (AAA) and stroke due to plaque rupture. Failure in soft tissues caused by medical devices is also a medical challenge. In all these cardiovascular events a better prediction of failure of the tissue and a better understanding about the tissue properties will help in predicament and treatment. For example the diameter-based indication for surgical repair of AAA and TAAs is not sufficient and refined methods are needed. In this thesis failures of some soft vascular tissues, was studied. Experiments have been combined with numerical modeling to understand the elastic and failure properties of AAA, TAA and plaque tissue as well as the ventricular wall. Vascular tissue is anisotropic, time-dependent, nonlinear and shows large deformations. Among others this thesis showed the importance of viscoelasticity which motivates to develop a new continuum mechanical framework. In addition a large part of this thesis dealt with anisotropy of vascular tissue. For the first time the collagen orientation distribution in the AAA wall has been identified. Collagen and its distribution orientation is also an important feature of this tissue. There was a correlation between the strength and stiffness of the AAA samples with the decreasing wall thickness. Increased stiffness was found in the aortic wall of patients with chronic obstructive pulmonary disease (COPD) compared to patients that did not have COPD. As well as difference in stiffness of TAA tissue, in patients with non-pathologic and pathologic aortic valves. Some of the findings in this thesis could have a long-term consequence for management of risk of rupture in AAA, TAA and plaque.

Place, publisher, year, edition, pages
Stockholm: KTH Royal Institute of Technology, 2013. x, 30 p.
Series
Trita-HFL, ISSN 1104-6813 ; 0545
National Category
Other Mechanical Engineering
Identifiers
urn:nbn:se:kth:diva-122840 (URN)978-91-7501-798-3 (ISBN)
Public defence
2013-06-07, Sal D2, Lindstedtsvägen 5, KTH, Stockholm, 09:00 (English)
Opponent
Supervisors
Note

QC 20130528

Available from: 2013-05-28 Created: 2013-05-28 Last updated: 2013-05-29Bibliographically approved

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