Optimal length of smooth muscle assessed by a microstructurally and statistically based constitutive model
2011 (English)In: Computer Methods in Biomechanics and Biomedical Engineering, ISSN 1025-5842, Vol. 14, no 1, 43-52 p.Article in journal (Refereed) Published
Smooth muscle exhibits an optimal length at which it is able to generate a maximum amount of force. In this study, the optimal length is assessed by use of a microstructurally and statistically based constitutive model for smooth muscle. The model is based on the sliding filament theory, and a modified version of Hill's mechanical model was adopted. It was conjectured, that a variation in the overlap in the actomyosin contractile units together with a statistical dispersion in the size of the dense bodies are responsible for the optimal length characteristics. The influence of contractile unit length, dense body size and dense body compliance was investigated, and the model was fully able to predict experimental data. The results indicate that the compliance of the dense bodies does not contribute significantly to the total compliance of the contractile apparatus.
Place, publisher, year, edition, pages
2011. Vol. 14, no 1, 43-52 p.
smooth muscle, optimal length, constitutive model
IdentifiersURN: urn:nbn:se:kth:diva-31357DOI: 10.1080/10255842.2010.493521ISI: 000287536600005ScopusID: 2-s2.0-79251497993OAI: oai:DiVA.org:kth-31357DiVA: diva2:404363
QC 201103162011-03-162011-03-142011-03-16Bibliographically approved