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Covalent VEGF protein immobilization on resorbable polymeric surfaces
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Polymer Technology.ORCID iD: 0000-0002-1631-1781
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Polymer Technology.
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Polymer Technology.
2011 (English)In: POLYMERS FOR ADVANCED TECHNOLOGIES , 2011, Vol. 22, no 1, 166-171 p.Conference paper, Published paper (Refereed)
Abstract [en]

Vascular endothelial growth factor (VEGF) type protein, a potent angiogenic effector molecule, was successfully covalently immobilized onto the surfaces of the resorbable polymers poly(L-lactic acid) (PLLA) and poly(epsilon-caprolactone) through a three-step strategy. The surfaces were first covalently grafted with poly(acrylic acid) using non-destructive and solvent-free vapor-phase grafting. A diamine spacer was coupled to the carboxylic acid pendant groups on the graft chains using 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride/N-hydroxysuccinimide chemistry and VEGF was finally covalently attached to the amine linkers. The chemistry and topography of the modified substrates were quantitatively and qualitatively verified with X-ray photoelectron spectroscopy, attenuated total reflectance-Fourier transform infrared spectrometry, UV-VIS, scanning electron microscopy, and enzyme-linked immunosorbent assay.

Place, publisher, year, edition, pages
2011. Vol. 22, no 1, 166-171 p.
Series
Polymers for advanced technologies, ISSN 1042-7147
Keyword [en]
polylactide, poly(epsilon-caprolactone), vapor-phase grafting, VEGF, surface
National Category
Polymer Chemistry
Identifiers
URN: urn:nbn:se:kth:diva-30507DOI: 10.1002/pat.1811ISI: 000285881800024OAI: oai:DiVA.org:kth-30507DiVA: diva2:404364
Conference
10th International Conference on Polymers for Advanced Technologies (PAT 2009)
Note
QC 20110316Available from: 2011-03-16 Created: 2011-02-28 Last updated: 2011-03-16Bibliographically approved

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Edlund, Ulrica

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