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On comparison between polymer- and phospholipid-shelled microbubbles for contrast-enhanced ultrasound measurements of capillary microcirculation.
KTH, School of Technology and Health (STH), Medical Engineering.ORCID iD: 0000-0002-3699-396X
KTH, School of Technology and Health (STH), Medical Engineering.
CLINTEC, Department of Radiology, Karolinska University Hospital.
Dipartimento di Chimica, Università di Roma Tor Vergata.
2011 (English)In: Proceedings of the 34th Scandinavian Symposium on Physical Acoustics / [ed] Rolf J. Korneliussen, 2011Conference paper (Refereed)
Abstract [en]

The focus of contrast-enhanced ultrasound research has developed beyond visualizing the blood circulation to new areas such as perfusion and molecular imaging, drug and gene therapy. This work compares the application of polymer- and phospholipid-shelled ultrasound contrast agents (UCAs) employed for characterization of the capillary microcirculation. To quantify microcirculation destruction/replenishment technique with varied time intervals between destructive and monitoring pulses is used. The dependence of the peak-to-peak amplitude of backscattered wave versus pulse interval is fitted with an exponential function of the time y=A(1-exp(-βt)) , where A represents capillary volume and the time constant β represents velocity of the flow. Working under assumption that backscattered signal is linearly proportional to the microbubble concentration, for both types of the UCAs it is observed that capillary volume, A, is in linearly relationship with the concentration, and the flow velocity, β, remain unchanged. Using 500 µm diameter microtube as a vessel phantom a delay of about 0.25 s in evaluation of the perfusion characteristics is found for the phospholipid-shelled UCA, while polymer-shelled UCA provide response immediately. In conclusion, these results suggest that the novel polymer-shelled microbubbles have a potential to be used for perfusion evaluation.

Place, publisher, year, edition, pages
Keyword [en]
Ultrasound, contrast agents, microbubbles, polymer, capillary, circulation
National Category
Medical Laboratory and Measurements Technologies
Research subject
SRA - Molecular Bioscience
URN: urn:nbn:se:kth:diva-31961OAI: diva2:407647
EU, FP7, Seventh Framework Programme, 245572
QC 20111005Available from: 2011-03-31 Created: 2011-03-31 Last updated: 2011-10-05Bibliographically approved

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