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Ultrasome: efficient aberration caller for copy number studies of ultra-high resolution
KTH, School of Electrical Engineering (EES), Automatic Control.
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2009 (English)In: Bioinformatics, ISSN 1367-4803, E-ISSN 1460-2059, Vol. 25, no 8, 1078-1079 p.Article in journal (Refereed) Published
Abstract [en]

Motivation: Multimillion-probe microarrays allow detection of gains and losses of chromosomal material at unprecedented resolution. However, the data generated by these arrays are several-fold larger than data from earlier platforms, creating a need for efficient analysis tools that scale robustly with data size. 

Results: We developed a new aberration caller, Ultrasome, that delineates genomic changes-of-interest with dramatically improved efficiency. Ultrasome shows near-linear computational complexity and processes latest generation copy number arrays about 10 000 times faster than standard methods with preserved analytic accuracy.

Place, publisher, year, edition, pages
2009. Vol. 25, no 8, 1078-1079 p.
Keyword [en]
DNA, accuracy, article, chromosome aberration, computer program, controlled study, DNA microarray, gene number, human, human cell, information processing, intermethod comparison, mathematical analysis, priority journal, receiver operating characteristic, Ultrasome, Algorithms, Chromosome Aberrations, Computational Biology, Gene Dosage, Gene Expression Profiling, Oligonucleotide Array Sequence Analysis, Polymorphism, Single Nucleotide
National Category
Bioinformatics and Systems Biology
URN: urn:nbn:se:kth:diva-32516DOI: 10.1093/bioinformatics/btp091ISI: 000265094400015ScopusID: 2-s2.0-64549088918OAI: diva2:410939
QC 20110415Available from: 2011-04-15 Created: 2011-04-15 Last updated: 2011-04-15Bibliographically approved

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