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Polymer-Shelled Ultrasound Contrast Agents with controlled size and polydispersity.
KTH, School of Technology and Health (STH), Medical Engineering.
KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Structural Biotechnology.ORCID iD: 0000-0002-9604-0511
KTH, School of Technology and Health (STH), Medical Engineering.ORCID iD: 0000-0002-3699-396X
CLINTEC, Department of Medical Imaging and Technology, Karolinska Institute.
2011 (English)In: Nanomedicine: Nanotechnology, Biology & Medicine, 2011Conference paper (Refereed)
Abstract [en]

Ultrasound imaging techniques can be greatly improved by the use of ultrasound contrast agents (UCAs). Gas bubbles encapsulated into biocompatible polymer shell are of particular interest of this work. Shell of the bubbles produced from Poly-Vinyl-Alcohol (PVA) offers considerable chemical versatility and stability. However, questions regarding the size and polydispersity of the microbubbles must be further investigated. The ideal UCAs should not obstruct the blood flow in pulmonary capillaries which diameter is less than 10 μm. From the technical perspective UCAs should modify the acoustic properties of a region of interest, by increasing backscattered efficiency. In order to enhance the ultrasound response UCAs should be engineered with narrow size distribution. In the present work PVA-shelled UCAs with controlled size and polydispersity is manufactured under varied parameters of the manufacturing protocol. It was observed that temperature of the surrounding atmosphere has major effect on the size of the UCAs, while polydispersity is regulated by geometry and speed of the disperser. Finally, the acoustic response of these microbubbles is tested using developed ultrasound test rig. The enhancement of the backscattered power of about 25 dB from a suspension of the microbubbles is observed at 5 MHz ultrasound frequency. Keeping in mind that in clinical practice ultrasound scatter from the blood is of about 30 dB weaker than scatter from surrounding tissue, introduction of novel PVA microbubbles will potentially improve diagnosis of the cardiovascular patients.

Place, publisher, year, edition, pages
Keyword [en]
ultrasound, contrast agent, polymer, PVA, backscattering
National Category
Fluid Mechanics and Acoustics Medical Laboratory and Measurements Technologies Other Engineering and Technologies
Research subject
SRA - Molecular Bioscience
URN: urn:nbn:se:kth:diva-32573OAI: diva2:411092
8th International Conference on Nanosciences & Nanotechnologies (NN11) 12-15 July 2011, Thessaloniki, Greece.

QC 20111021

Available from: 2011-04-15 Created: 2011-04-15 Last updated: 2016-06-15Bibliographically approved

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