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Comprehensive analysis of the substitution pattern in dextran ethers with respect to the reaction conditions
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2009 (English)In: Analytical and Bioanalytical Chemistry, ISSN 1618-2642, E-ISSN 1618-2650, Vol. 395, no 6, 1749-1768 p.Article in journal (Refereed) Published
Abstract [en]

Dextrans from Leuconostoc ssp., alpha-1,6-linked glucans branched at O-3, were O-methylated in DMSO with lithium dimsyl and methyl iodide under various conditions. Methyl substituent distribution was comprehensively studied in the terminal, internal, and branched glucosyl units and along and over the dextran macromolecules. The order of reactivity was O-2>O-4 >= O-3. The methyl pattern in the glucosyl units significantly deviates from a random distribution with enhanced amounts of un- and trisubstituted moieties. This deviation was found to proceed on macromolecular level by means of ESI-MS of perdeuteromethylated and partially depolymerized methyl dextrans. Heterogeneity was much more pronounced than for methyl amylose prepared under comparable conditions. DS gradients in and over the material are discussed with respect to dextran structure and the mechanism of Li dimsyl alkylation. For comparison, cyanoethyl dextrans were prepared by sodium hydroxide catalyzed addition of acrylonitrile. Monomer analysis of cyanoethyl dextrans revealed that this thermodynamically controlled reaction gave a random substitution pattern with 48% of cyanoethyl groups at O-2, 33% at O-4, and 19% at O-3.

Place, publisher, year, edition, pages
2009. Vol. 395, no 6, 1749-1768 p.
Keyword [en]
Biomaterials, GC, Mass spectrometry, Polymers
National Category
Dentistry Chemical Sciences
Identifiers
URN: urn:nbn:se:kth:diva-33119DOI: 10.1007/s00216-009-3013-4ISI: 000271395600020Scopus ID: 2-s2.0-70449559232OAI: oai:DiVA.org:kth-33119DiVA: diva2:413472
Note
QC 20110428Available from: 2011-04-28 Created: 2011-04-28 Last updated: 2017-12-11Bibliographically approved

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