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Modelling the ion distribution in single, binary and ternary ion exchanged Azeolite
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Polymeric Materials.
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Polymeric Materials.ORCID iD: 0000-0002-2139-7460
KTH, School of Industrial Engineering and Management (ITM), Materials Science and Engineering, Materials Process Science.
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Polymeric Materials.ORCID iD: 0000-0002-5394-7850
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2011 (English)In: Microporous and Mesoporous Materials, ISSN 1387-1811Article in journal (Other academic) Published
Place, publisher, year, edition, pages
National Category
Materials Engineering Polymer Chemistry
URN: urn:nbn:se:kth:diva-33589OAI: diva2:416229
QS 2011Available from: 2011-05-11 Created: 2011-05-11 Last updated: 2011-05-11Bibliographically approved
In thesis
1. Antimicrobial Polymer Composites for Medical Applications
Open this publication in new window or tab >>Antimicrobial Polymer Composites for Medical Applications
2011 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The current study and discuss the long-term properties of biomedical polymers in vitro and invivo and presents means to design and manufacture antimicrobial composites. Antimicrobialcomposites with reduced tendency for biofilm formation should lead to lower risk for medicaldevice associated infection.The first part analyse in vivo degradation of invasive silicone rubber tracheostomy tubes andpresents degradation mechanism, degradation products and the estimated lifetime of thematerials.. It was found that silicone tubes undergo hydrolysis during the long-term exposurein vivo, which in turn results in decreased stability of the polymer due to surface alterationsand the formation of low molecular weight compounds.The second part of the study presents the manufacturing of composites with single, binary andternary ion-exchanged zeolites as an antimicrobial agent. The ion distribution and release ofthe zeolites and the antimicrobial efficiency of the different systems showed that single silverion-exchanged zeolite was superior to the other samples. Antimicrobial composites wereprepared by mixing the above-mentioned zeolites and pure zeolite (without any ion) withdifferent fractions into polyether (TPU), polyether (PEU) polyurethane and silicone rubber.The antimicrobial efficiency of binary and ternary ion-exchanged samples was similar whichis thought to be due to the ion distribution in the crystal structure.The changes in the mechanical and surface properties of the composites due to the zeolitecontent demonstrated that the increasing zeolite content reduced the mechanical propertieswhile the surface properties did not change significantly. The antimicrobial tests showed thatthe silver-containing composite was the most efficient among all the other samples. Thebinary and ternary ion-exchanged composites expressed similar antimicrobial efficiency as itwas seen previously for the different zeolite systems. Biocompatibility was studied byexposure to artificial body fluids to simulate the degradation of the composites in the humanbody. Significant changes were observed in the morphology, the surface properties and the chemical structure.

Place, publisher, year, edition, pages
Stockholm: KTH Royal Institute of Technology, 2011. 79 p.
Trita-CHE-Report, ISSN 1654-1081 ; 2011:19
medical polymers, antimicrobial, body fluids, degradation
National Category
Polymer Chemistry
urn:nbn:se:kth:diva-33393 (URN)978-91-7415-899-1 (ISBN)
Public defence
2011-05-13, F3, Lindstedtsvägen 23 KTH, Stockholm, 13:00 (English)
QC 20110511Available from: 2011-05-11 Created: 2011-05-05 Last updated: 2011-05-11Bibliographically approved

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Kaali, PeterStrömberg, EmmaAune, Ragnhild E.Karlsson, Sigbritt
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