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The influence of Ag(+), Zn(2+) and Cu(2+) exchanged zeolite on antimicrobial and long term in vitro stability of medical grade polyether polyurethane
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Polymeric Materials.
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Polymeric Materials.ORCID iD: 0000-0002-2139-7460
KTH, School of Industrial Engineering and Management (ITM), Materials Science and Engineering, Materials Process Science.
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2011 (English)In: Express Polymer letters, ISSN 1788-618X, Vol. 5, no 12, 1028-1040 p.Article in journal (Refereed) Published
Abstract [en]

This study aims to investigate the limitations and applicability of different ion exchanged zeolites as antimicrobial additive in thermoplastic polyether type polyurethanes. These composites were designed to improve the health quality of hospitalized patients by expressing both biocompatibility and relevant antimicrobial activity. The zeolites were exchanged with silver, copper and zinc ions and single, binary and ternary ion-exchanged zeolite-polyurethane composites were prepared. The antimicrobial activity and the resistance of the composites against the human environment play vital role in the applicability of the materials as a medical device therefore these properties were investigated. The antimicrobial test were performed on Methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa and Candida tropicalis. The tests showed that the efficiency of the silver ions is superior to the other single ionic systems. Besides, the binary and ternary ion-exchanged samples had similar antimicrobial efficiency regardless the type of the ions in the zeolite. The biocompatibility tests were carried out in-vitro in artificial body fluids for a period of 12 weeks. As a result of the in-vitro test, degradation of the composites were observed and the structural changes of the materials were detected and described by Scanning Electron Microscopy, Contact Angle measurements and Attenuated Total Reflection Fourier Transform Infrared Spectroscopy.

Place, publisher, year, edition, pages
2011. Vol. 5, no 12, 1028-1040 p.
Keyword [en]
biocomposites, body fluid, ion-exchanged zeolite, antibacterial, in-vitro test
National Category
Polymer Chemistry
URN: urn:nbn:se:kth:diva-33590DOI: 10.3144/expresspolymlett.2011.101ISI: 000296092700002ScopusID: 2-s2.0-80053918726OAI: diva2:416231
Swedish Research Council
QS 2011. Updated from submitted to published. Previous title: The influence of Ag+, Zn2+ and Cu2+ exchanged zeolite on antimicrobial and long term in vitro stability of medical grade polyether polyurethaneAvailable from: 2011-05-11 Created: 2011-05-11 Last updated: 2011-11-17Bibliographically approved
In thesis
1. Antimicrobial Polymer Composites for Medical Applications
Open this publication in new window or tab >>Antimicrobial Polymer Composites for Medical Applications
2011 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The current study and discuss the long-term properties of biomedical polymers in vitro and invivo and presents means to design and manufacture antimicrobial composites. Antimicrobialcomposites with reduced tendency for biofilm formation should lead to lower risk for medicaldevice associated infection.The first part analyse in vivo degradation of invasive silicone rubber tracheostomy tubes andpresents degradation mechanism, degradation products and the estimated lifetime of thematerials.. It was found that silicone tubes undergo hydrolysis during the long-term exposurein vivo, which in turn results in decreased stability of the polymer due to surface alterationsand the formation of low molecular weight compounds.The second part of the study presents the manufacturing of composites with single, binary andternary ion-exchanged zeolites as an antimicrobial agent. The ion distribution and release ofthe zeolites and the antimicrobial efficiency of the different systems showed that single silverion-exchanged zeolite was superior to the other samples. Antimicrobial composites wereprepared by mixing the above-mentioned zeolites and pure zeolite (without any ion) withdifferent fractions into polyether (TPU), polyether (PEU) polyurethane and silicone rubber.The antimicrobial efficiency of binary and ternary ion-exchanged samples was similar whichis thought to be due to the ion distribution in the crystal structure.The changes in the mechanical and surface properties of the composites due to the zeolitecontent demonstrated that the increasing zeolite content reduced the mechanical propertieswhile the surface properties did not change significantly. The antimicrobial tests showed thatthe silver-containing composite was the most efficient among all the other samples. Thebinary and ternary ion-exchanged composites expressed similar antimicrobial efficiency as itwas seen previously for the different zeolite systems. Biocompatibility was studied byexposure to artificial body fluids to simulate the degradation of the composites in the humanbody. Significant changes were observed in the morphology, the surface properties and the chemical structure.

Place, publisher, year, edition, pages
Stockholm: KTH Royal Institute of Technology, 2011. 79 p.
Trita-CHE-Report, ISSN 1654-1081 ; 2011:19
medical polymers, antimicrobial, body fluids, degradation
National Category
Polymer Chemistry
urn:nbn:se:kth:diva-33393 (URN)978-91-7415-899-1 (ISBN)
Public defence
2011-05-13, F3, Lindstedtsvägen 23 KTH, Stockholm, 13:00 (English)
QC 20110511Available from: 2011-05-11 Created: 2011-05-05 Last updated: 2011-05-11Bibliographically approved

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Kaali, PeterStrömberg, EmmaAune, Ragnhild E.Karlsson, Sigbritt
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