Functional and highly porous scaffolds for biomedical applications
2011 (English)In: Macromolecular Bioscience, ISSN 1616-5187, E-ISSN 1616-5195, Vol. 11, no 10, 1432-1442 p.Article in journal (Refereed) Published
Highly porous functional scaffolds were obtained from linear and cross-linked multifunctional poly(ε-caprolactone) and poly(L-lactide). The polymers were synthesized by ring-opening polymerization of ε-caprolactone and L-lactide using poly(but-2-ene-1,4-diyl malonate) (PBM) as macroinitiator and stannous 2-ethylhexanoate. The presence of a double bond in each repeating unit of PBM enabled cross-linking of both scaffolds and films. Soft and flexible scaffolds were created from cross-linked PBM. The mechanical properties of scaffolds and films were evaluated under cyclic conditions, with a focus on the compositions and molecular weights. It was obvious that PBM in the polymers and its cross-linking ability resulted in tunable material characteristics, including an increased ability to recover after repeated loading.
Place, publisher, year, edition, pages
2011. Vol. 11, no 10, 1432-1442 p.
functionalization of polymers, porous scaffolds, ring-opening polymerization, tissue engineering
IdentifiersURN: urn:nbn:se:kth:diva-34173DOI: 10.1002/mabi.201100166ISI: 000296138500016ScopusID: 2-s2.0-80053929414OAI: oai:DiVA.org:kth-34173DiVA: diva2:419656
FunderSwedish Research Council, 2008-5538