Change search
ReferencesLink to record
Permanent link

Direct link
5-methyltetrahydrofolate is photosensitive in the presence of riboflavin
KTH, School of Engineering Sciences (SCI), Applied Physics.
Show others and affiliations
2008 (English)In: Photochemical and Photobiological Sciences, ISSN 1474-905X, E-ISSN 1474-9092, Vol. 7, no 7, 814-818 p.Article in journal (Refereed) Published
Abstract [en]

5-Methyltetrahydrofolate (5MTHF) is the main form of folate in human plasma, and an important vitamin for human health. Photodegradation of folates may have played a role in the development of different human skin colours. 5MTHF can be degraded directly by exposure to ultraviolet radiation or by exposure to visible light in the presence of endogenous sensitizers like riboflavin (RF). These photochemical reactions were studied by absorption spectroscopy. While 5MTHF is stable under UV and visible light exposure in pure aqueous media, it is quickly degraded in the presence of RF during UVA and blue light exposure. The degradation of 5MTHF is dependent on the concentration of RF, but not on the concentration of 5MTHF itself. UVA and blue light gave similar reactions. Further investigations are necessary to evaluate the consequences of large light exposures in vivo in humans. Our findings should be taken into the ongoing discussion about the development of human skin colours. Due to the presence of RF in human blood, folate can be significantly degraded during prolonged or intense blue light exposure. Thus, a dark skin colour may be favourable for prevention of folate degradation under high solar fluence rates, such as in equatorial areas.

Place, publisher, year, edition, pages
2008. Vol. 7, no 7, 814-818 p.
Keyword [en]
National Category
Radiology, Nuclear Medicine and Medical Imaging
URN: urn:nbn:se:kth:diva-34167DOI: 10.1039/b718907aISI: 000257426200008ScopusID: 2-s2.0-46449085732OAI: diva2:419981
QC 20110530Available from: 2011-05-30 Created: 2011-05-27 Last updated: 2011-05-30Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textScopus

Search in DiVA

By author/editor
Lu, Xiao Yun
By organisation
Applied Physics
In the same journal
Photochemical and Photobiological Sciences
Radiology, Nuclear Medicine and Medical Imaging

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 21 hits
ReferencesLink to record
Permanent link

Direct link