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Multinuclear NMR studies of the interaction of metal ions with adenine-nucleotides
KTH, School of Chemical Science and Engineering (CHE), Chemistry, Inorganic Chemistry.ORCID iD: 0000-0002-7552-1076
2008 (English)In: Coordination chemistry reviews, ISSN 0010-8545, E-ISSN 1873-3840, Vol. 252, no 21-22, 2362-2380 p.Article, review/survey (Refereed) Published
Abstract [en]

It is well-known that metal ion complexes are essential in various biological systems, including those with adenosine nucleotides which are substrates for a large number of enzymatic processes. The interactions of various metal ions with adenosine nucleotides have been intensively studied by multinuclear NMR spectroscopy. Nucleotides are polydentate ligands with various potential binding sites, including nitrogen atoms on the purine base, hydroxyl groups on the ribose sugar, and negatively charged oxygen atoms in the phosphate group. Depending on the experimental conditions (e.g. pH, concentration range, etc.) and on the size and nature of the metal ions, monodentate, or multidentate coordination to these donor atoms are possible. The review focuses on the applications of different NMR techniques in identifying the stoichiometry and the mode of metal binding in complexes formed with the most important adenosine nucleotides, like adenosine-5'-mono-, di- and triphosphates (AMP, ADP and ATP). Ligand exchange dynamics for some metal ion complexes are also presented.

Place, publisher, year, edition, pages
2008. Vol. 252, no 21-22, 2362-2380 p.
Keyword [en]
Metal ions, Nucleotides, NMR spectroscopy, Solution coordination chemistry, Complex formation
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:kth:diva-34271DOI: 10.1016/j.ccr.2008.03.002ISI: 000259897800012Scopus ID: 2-s2.0-50849132216OAI: oai:DiVA.org:kth-34271DiVA: diva2:420339
Note
QC 20110601Available from: 2011-06-01 Created: 2011-05-31 Last updated: 2017-12-11Bibliographically approved

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Szabo, Zoltan

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