Change search
ReferencesLink to record
Permanent link

Direct link
Dissection Properties and Mechanical Strength of Tissue Components in Human Carotid Bifurcations
KTH, School of Engineering Sciences (SCI), Solid Mechanics (Dept.).
2011 (English)In: Annals of Biomedical Engineering, ISSN 0090-6964, E-ISSN 1573-9686, Vol. 39, no 6, 1703-1719 p.Article in journal (Refereed) Published
Abstract [en]

Carotid artery dissections can be triggered by several factors. The underlying biomechanical phenomena and properties are unclear. This study investigates the dissection properties of 62 human carotid bifurcations using two experimental methods: direct tension and peeling tests. Direct tension tests study the mechanical strength of the tissue components in radial direction, while peeling tests quantify the fracture energy required to propagate a dissection in a tissue. Results show that the interface between the healthy adventitia and media has the highest radial failure stress (132 +/- A 20 kPa, mean +/- A SD, n = 25), whereas the lowest value occurs between the diseased intima and media (104 +/- A 24 kPa, n = 18). The radial tissue strength at the bifurcation is the highest compared with locations that are away from the central region of the bifurcation. Force/width values required to separate the individual layers and to dissect the media in the circumferential direction are always lower than related values in the axial direction, suggesting anisotropic dissection properties. Dissection energies per reference area generated during the peeling tests are also lower for strips in the circumferential direction than for axial strips, and they vary significantly with the location, as shown for the media. Histological investigations demonstrate that interfacial ruptures mainly occur in the media in both types of tests and are 2-5 elastic lamellae away from the external and internal elastic laminae. A remarkably "rougher" dissection surface is generated during axial peeling tests when compared with tests performed in the circumferential direction.

Place, publisher, year, edition, pages
2011. Vol. 39, no 6, 1703-1719 p.
Keyword [en]
Carotid dissection, Failure stress, Dissection property, Human carotid bifurcation
National Category
Other Industrial Biotechnology
URN: urn:nbn:se:kth:diva-34399DOI: 10.1007/s10439-011-0264-yISI: 000290724900010ScopusID: 2-s2.0-79958859507OAI: diva2:420920
QC 20110607Available from: 2011-06-07 Created: 2011-06-07 Last updated: 2011-06-07Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textScopus

Search in DiVA

By author/editor
Holzapfel, Gerhard A.
By organisation
Solid Mechanics (Dept.)
In the same journal
Annals of Biomedical Engineering
Other Industrial Biotechnology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 39 hits
ReferencesLink to record
Permanent link

Direct link