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Raman reporter-coated gold nanorods and their applications in multimodal optical imaging of cancer cells
KTH, School of Information and Communication Technology (ICT), Centres, Zhejiang-KTH Joint Research Center of Photonics, JORCEP.
KTH, School of Information and Communication Technology (ICT), Centres, Zhejiang-KTH Joint Research Center of Photonics, JORCEP.
KTH, School of Information and Communication Technology (ICT), Centres, Zhejiang-KTH Joint Research Center of Photonics, JORCEP.
KTH, School of Information and Communication Technology (ICT), Centres, Zhejiang-KTH Joint Research Center of Photonics, JORCEP. KTH, School of Electrical Engineering (EES), Electromagnetic Engineering.ORCID iD: 0000-0002-3401-1125
2011 (English)In: Analytical and Bioanalytical Chemistry, ISSN 1618-2642, E-ISSN 1618-2650, Vol. 400, no 9, 2793-2800 p.Article in journal (Refereed) Published
Abstract [en]

We report the preparation of a kind of surface-enhanced Raman scattering (SERS) tags and explore their applications in multifunctional optical imaging of cancer cells. The proposed nanoparticles (SERS tags) are prepared by connecting dye molecules directly onto the surfaces of gold nanorods through Au-S or Au-N interactions. The dye molecules are used as Raman reporters, while gold nanorods are used as enhanced materials due to their localized surface plasmon resonance effect. Multilayered polymers are further coated onto the surfaces of the nanoparticles to reach better stability and biocompatibility. Gold nanorods with different aspect ratios and different dye molecules conjugated are compared in order to achieve the diversity of SERS tags and find out the optimized condition of SERS tags with the highest signal intensity. Our experiments show that the resulting nanoparticles, which are uptaken by cancer cells, can provide not only dark field cells images but also multiplexing SERS images.

Place, publisher, year, edition, pages
2011. Vol. 400, no 9, 2793-2800 p.
Keyword [en]
SERS tags, Dye molecules, Raman bands, Multiplexing image
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:kth:diva-34683DOI: 10.1007/s00216-011-4894-6ISI: 000291037800013Scopus ID: 2-s2.0-79958105977OAI: oai:DiVA.org:kth-34683DiVA: diva2:422446
Note

QC 20110613

Available from: 2011-06-13 Created: 2011-06-13 Last updated: 2017-12-11Bibliographically approved

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He, Sailing

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Jiang, LiQian, JunCai, FuhongHe, Sailing
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