Macromolecular Design of Aliphatic Polyesters with Maintained Mechanical Properties and a Rapid, Customized Degradation Profile
2011 (English)In: Biomacromolecules, ISSN 1525-7797, E-ISSN 1526-4602, Vol. 12, no 6, 2382-2388 p.Article in journal (Refereed) Published
An innovative type of triblock copolymer that maintains and even increases the mechanical properties of poly(L-lactide) (PLLA) and poly(epsilon-caprolactone) (PCL) with a controlled, predictable, and rapid degradation profile has been synthesized. Elastic triblock copolymers were formed from the hydrophobic and crystalline PLLA and PCL with an amorphous and hydrophilic middle block of poly(but-2-ene-1,4-diyl malonate) (PBM). The polymers were subjected to degradation in PBS at 37 degrees C for up to 91 days. Prior to degradation, ductility of the PLLA-PBM-PLLA was approximately 4 times greater than that of the homopolymer of PLLA, whereas the modulus and tensile stress at break were unchanged. A rapid initial hydrolysis in the amorphous PBM middle block changed the microstructure from triblock to diblock with a significant reduction in ductility and molecular weight. The macromolecular structure of the triblock copolymer of PLLA and PBM generates a more flexible and easier material to handle during implant, with the advantage of a customized degradation profile, demonstrating its potential use in future biomedical applications.
Place, publisher, year, edition, pages
2011. Vol. 12, no 6, 2382-2388 p.
RING-OPENING POLYMERIZATION, EPSILON-CAPROLACTONE, L-LACTIDE, TRIMETHYLENE CARBONATE, HYDROLYTIC DEGRADATION, MULTIBLOCK COPOLYMERS, TRIBLOCK COPOLYMERS, BLOCK-COPOLYMERS, 1, 5-DIOXEPAN-2-ONE, POLYLACTONES
IdentifiersURN: urn:nbn:se:kth:diva-35634DOI: 10.1021/bm2004675ISI: 000291499900051ScopusID: 2-s2.0-79958840855OAI: oai:DiVA.org:kth-35634DiVA: diva2:429214
FunderSwedish Research Council, 2008-5538EU, European Research Council, 246776
QC 201107042011-07-042011-07-042011-08-30Bibliographically approved