An improved method for detecting and delineating genomic regions with altered gene expression in cancer
2008 (English)In: GENOME BIOL, ISSN 1474-760X, Vol. 9, no 1, R13- p.Article in journal (Refereed) Published
Genomic regions with altered gene expression are a characteristic feature of cancer cells. We present a novel method for identifying such regions in gene expression maps. This method is based on total variation minimization, a classical signal restoration technique. In systematic evaluations, we show that our method combines top-notch detection performance with an ability to delineate relevant regions without excessive over-segmentation, making it a significant advance over existing methods. Software (Rendersome) is provided.
Place, publisher, year, edition, pages
2008. Vol. 9, no 1, R13- p.
IdentifiersURN: urn:nbn:se:kth:diva-36416DOI: 10.1186/gb-2008-9-1-r13ISI: 000253779800021ScopusID: 2-s2.0-46249086537OAI: oai:DiVA.org:kth-36416DiVA: diva2:430720
QC 201107122011-07-122011-07-122011-07-12Bibliographically approved