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Bio-molecule-conjugated fluorescent organically modified silica nanoparticles as optical probes for cancer cell imaging
KTH, School of Biotechnology (BIO), Theoretical Chemistry (closed 20110512). KTH, School of Information and Communication Technology (ICT), Centres, Zhejiang-KTH Joint Research Center of Photonics, JORCEP.
KTH, School of Biotechnology (BIO), Theoretical Chemistry (closed 20110512). KTH, School of Information and Communication Technology (ICT), Centres, Zhejiang-KTH Joint Research Center of Photonics, JORCEP.
KTH, School of Biotechnology (BIO), Theoretical Chemistry (closed 20110512). KTH, School of Information and Communication Technology (ICT), Centres, Zhejiang-KTH Joint Research Center of Photonics, JORCEP.
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2008 (English)In: Vol. 16, no 24, 19568-19578 p.Article in journal (Refereed) Published
Abstract [en]

Organically modified silica nanoparticles doped with Nile Red were synthesized and characterized. Silica encapsulation is relatively transparent for light and can protect hydrophobic Nile Red against denaturalization induced by the extreme bio-environment, making the entire nanoparticle hydrophilic and possess stable optical properties. The nanoparticles were conjugated with bio-molecules ( such as apo-transferrin and folic acid), and our in vitro experiments revealed that these functionalized nanoparticles can serve as effective optical probes for specific targeting of cancer cells. As a preliminary study for future in vivo animal experiment, ORMOSIL nanoparticles were further co-conjugated with polyethyleneglycol (PEG) and apo-transferrin and the conjugates were also very good for in vitro targeting of HeLa cells. These bio-molecule functionalized ORMOSIL nanoparticles may serve as a robust tool for early diagnosis/therapy of cancer and other diseases.

Place, publisher, year, edition, pages
2008. Vol. 16, no 24, 19568-19578 p.
National Category
Industrial Biotechnology
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URN: urn:nbn:se:kth:diva-36430DOI: 10.1364/OE.16.019568ISI: 000261561900018Scopus ID: 2-s2.0-56749170938OAI: oai:DiVA.org:kth-36430DiVA: diva2:430818
Note

QC 20110712

Available from: 2011-07-12 Created: 2011-07-12 Last updated: 2017-12-11Bibliographically approved

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He, Sailing

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Qian, JunLi, XinWei, MingHe, Sailing
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Theoretical Chemistry (closed 20110512)Zhejiang-KTH Joint Research Center of Photonics, JORCEPElectromagnetic Engineering
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