Facile Synthesis of Degradable and Electrically Conductive Polysaccharide Hydrogels
2011 (English)In: Biomacromolecules, ISSN 1525-7797, E-ISSN 1526-4602, Vol. 12, no 7, 2601-2609 p.Article in journal (Refereed) Published
Degradable and electrically conductive polysaccharide hydrogels (DECPHs) have been synthesized by functionalizing polysaccharide with conductive aniline oligomers. DECPHs based on chitosan (CS), aniline tetramer (AT), and glutaraldehyde were obtained by a facile one-pot reaction by using the amine group of CS and AT under mild conditions, which avoids the multistep reactions and tedious purification involved in the synthesis of degradable conductive hydrogels in our previous work. Interestingly, these one-pot hydrogels possess good film-forming properties, electrical conductivity, and a pH-sensitive swelling behavior. The chemical structure and morphology before and after swelling of the hydrogels were verified by FT-IR, NMR, and SEM. The conductivity of the hydrogels was tuned by adjusting the content of AT. The swelling ratio of the hydrogels was altered by the content of tetraaniline and crosslinker. The hydrogels underwent slow degradation in a buffer solution. The hydrogels obtained by this facile approach provide new possibilities in biomedical applications, for example, biodegradable conductive hydrogels, films, and scaffolds for cardiovascular tissue engineering and controlled drug delivery.
Place, publisher, year, edition, pages
2011. Vol. 12, no 7, 2601-2609 p.
IdentifiersURN: urn:nbn:se:kth:diva-37165DOI: 10.1021/bm200389tISI: 000292617700021ScopusID: 2-s2.0-79960227637OAI: oai:DiVA.org:kth-37165DiVA: diva2:432318