Assessing the Degradation Profile of Functional Aliphatic Polyesters with Precise Control of the Degradation Products
2012 (English)In: Macromolecular Bioscience, ISSN 1616-5187, E-ISSN 1616-5195, Vol. 12, no 2, 260-268 p.Article in journal (Refereed) Published
The pre-polymer poly(but-2-ene-1,4-diyl malonate) (PBM) and a series of PBM-based materials are shown to be degradable under physiological conditions in vitro and they are therefore presented as potential materials for biomedical applications. Four different PBM-based materials are synthesized: a PBM homopolymer, crosslinked PBM with and without spacer, and a triblock copolymer of PBM and PLLA with the PBM as an amorphous middle block. The polymers are subjected to hydrolytic degradation in phosphate-buffered saline at pH = 7.4 and 37 °C. The results show that all the PBM-based materials degrade without a rapid release of acidic degradation products or any substantial lowering of the pH that might jeopardize their biocompatibility.
Place, publisher, year, edition, pages
2012. Vol. 12, no 2, 260-268 p.
biocompatibility, degradation products, polyesters
IdentifiersURN: urn:nbn:se:kth:diva-38610DOI: 10.1002/mabi.201100288ISI: 000299825500012PubMedID: 22095708ScopusID: 2-s2.0-84856583645OAI: oai:DiVA.org:kth-38610DiVA: diva2:437808
FunderSwedish Research Council, 2008-5538