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Contrast-enhanced dual-energy subtraction imaging using electronic spectrum-splitting and multi-prism x-ray lenses
KTH, School of Engineering Sciences (SCI), Physics, Medical Imaging.
KTH, School of Engineering Sciences (SCI), Physics, Medical Imaging.
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2008 (English)In: Medical Imaging 2008 - Physics of Medical Imaging: PTS 1-3 / [ed] Hsieh, J; Samei, E, 2008, Vol. 6913, 91310-91310 p.Conference paper (Refereed)
Abstract [en]

Dual-energy subtraction imaging (DES) is a method to improve the detectability of contrast agents over a lumpy background. Two images, acquired at x-ray energies above and below an absorption edge of the agent material, are logarithmically subtracted, resulting in suppression of the signal from the tissue background and a relative enhancement of the signal from the agent. Although promising, DES is still not widely used in clinical practice. One reason may be the need for two distinctly separated x-ray spectra that are still close to the absorption edge, realized through dual exposures which may introduce motion unsharpness. In this study, electronic spectrum-splitting with a silicon-strip detector is theoretically and experimentally investigated for a mammography model with iodinated contrast agent. Comparisons are made to absorption imaging and a near-ideal detector using a signal-to-noise ratio that includes both statistical and structural noise. Similar to previous studies, heavy absorption filtration was needed to narrow the spectra at the expense of a large reduction in x-ray flux. Therefore, potential improvements using a chromatic multi-prism x-ray lens (MPL) for filtering were evaluated theoretically. The MPL offers a narrow tunable spectrum, and we show that the image quality can be improved compared to conventional filtering methods.

Place, publisher, year, edition, pages
2008. Vol. 6913, 91310-91310 p.
, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, ISSN 0277-786X ; 6913
Keyword [en]
mammography, contrast-enhanced, dual-energy subtraction, x-ray optics, multi-prism lens, energy filtering
National Category
Biomedical Laboratory Science/Technology
URN: urn:nbn:se:kth:diva-38400DOI: 10.1117/12.770501ISI: 000256660300034ScopusID: 2-s2.0-43149123146ISBN: 978-0-8194-7097-3OAI: diva2:437824
Medical Imaging 2008 - Physics of Medical Imaging; San Diego, CA; 18 February 2008 through 21 February 2008
Available from: 2011-08-30 Created: 2011-08-25 Last updated: 2011-08-30Bibliographically approved

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ReferencesLink to record
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