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Acute normobaric hyperoxia transiently attenuates plasma erythropoietin concentration in healthy males: evidence against the 'normobaric oxygen paradox' theory
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2011 (English)In: Acta Physiologica, ISSN 1748-1708, E-ISSN 1748-1716, Vol. 202, no 1, 91-98 p.Article in journal (Refereed) Published
Abstract [en]

Aim: The purpose of the present study was to evaluate the 'normobaric oxygen paradox' theory by investigating the effect of a 2-h normobaric O(2) exposure on the concentration of plasma erythropoietin (EPO). Methods: Ten healthy males were studied twice in a single-blinded counterbalanced crossover study protocol. On one occasion they breathed air (NOR) and on the other 100% normobaric O(2) (HYPER). Blood samples were collected Pre, Mid and Post exposure; and thereafter, 3, 5, 8, 24, 32, 48, 72 and 96 h, and 1 and 2 weeks after the exposure to determine EPO concentration. Results: The concentration of plasma erythropoietin increased markedly 8 and 32 h after the NOR exposure (approx. 58% and approx. 52%, respectively, P < 0.05) as a consequence of its natural diurnal variation. Conversely, the O(2) breathing was followed by approx. 36% decrement of EPO 3 h after the exposure (P < 0.05). Moreover, EPO concentration was significantly lower in HYPER than in the NOR condition 3, 5 and 8 h after the breathing intervention (P < 0.05). Conclusion: In contrast to the 'normobaric oxygen paradox' theory, the present results indicate that a short period of normobaric O(2) breathing does not increase the EPO concentration in aerobically fit healthy males. Increased O(2) tension suppresses the EPO concentration 3 and 5 h after the exposure; thereafter EPO seems to change in a manner consistent with natural diurnal variation.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2011. Vol. 202, no 1, 91-98 p.
Keyword [en]
diurnal variation, erythropoiesis, hyperoxaemia, individual variability, oxygen therapy
National Category
Physiology
Identifiers
URN: urn:nbn:se:kth:diva-39186DOI: 10.1111/j.1748-1716.2011.02262.xISI: 000289250500010Scopus ID: 2-s2.0-79953690490OAI: oai:DiVA.org:kth-39186DiVA: diva2:439503
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QC 20110908

Available from: 2011-09-08 Created: 2011-09-08 Last updated: 2017-12-08Bibliographically approved

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Keramidas, Michail E.

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