Change search
ReferencesLink to record
Permanent link

Direct link
Acute normobaric hyperoxia transiently attenuates plasma erythropoietin concentration in healthy males: evidence against the 'normobaric oxygen paradox' theory
Show others and affiliations
2011 (English)In: Acta Physiologica, ISSN 1748-1708, E-ISSN 1748-1716, Vol. 202, no 1, 91-98 p.Article in journal (Refereed) Published
Abstract [en]

Aim: The purpose of the present study was to evaluate the 'normobaric oxygen paradox' theory by investigating the effect of a 2-h normobaric O(2) exposure on the concentration of plasma erythropoietin (EPO). Methods: Ten healthy males were studied twice in a single-blinded counterbalanced crossover study protocol. On one occasion they breathed air (NOR) and on the other 100% normobaric O(2) (HYPER). Blood samples were collected Pre, Mid and Post exposure; and thereafter, 3, 5, 8, 24, 32, 48, 72 and 96 h, and 1 and 2 weeks after the exposure to determine EPO concentration. Results: The concentration of plasma erythropoietin increased markedly 8 and 32 h after the NOR exposure (approx. 58% and approx. 52%, respectively, P < 0.05) as a consequence of its natural diurnal variation. Conversely, the O(2) breathing was followed by approx. 36% decrement of EPO 3 h after the exposure (P < 0.05). Moreover, EPO concentration was significantly lower in HYPER than in the NOR condition 3, 5 and 8 h after the breathing intervention (P < 0.05). Conclusion: In contrast to the 'normobaric oxygen paradox' theory, the present results indicate that a short period of normobaric O(2) breathing does not increase the EPO concentration in aerobically fit healthy males. Increased O(2) tension suppresses the EPO concentration 3 and 5 h after the exposure; thereafter EPO seems to change in a manner consistent with natural diurnal variation.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2011. Vol. 202, no 1, 91-98 p.
Keyword [en]
diurnal variation, erythropoiesis, hyperoxaemia, individual variability, oxygen therapy
National Category
URN: urn:nbn:se:kth:diva-39186DOI: 10.1111/j.1748-1716.2011.02262.xISI: 000289250500010ScopusID: 2-s2.0-79953690490OAI: diva2:439503

QC 20110908

Available from: 2011-09-08 Created: 2011-09-08 Last updated: 2016-04-26Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textScopus

Search in DiVA

By author/editor
Keramidas, Michail E.Eiken, Ola
By organisation
Environmental Physiology
In the same journal
Acta Physiologica

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 45 hits
ReferencesLink to record
Permanent link

Direct link