Change search
ReferencesLink to record
Permanent link

Direct link
Inflammatory markers and heart rate variability in women with coronary heart disease
KTH, School of Technology and Health (STH), Ergonomics (Closed 20130701). (Ergonomi)
Show others and affiliations
2004 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 256, no 5, 421-428 p.Article in journal (Refereed) Published
Abstract [en]

Purpose. Both heart rate variability (HRV) and inflammatory markers are carrying prognostic information in coronary heart disease (CHD), however, we know of no studies examining their relation in CHD. The aim of this study, therefore, was,to assess the association between HRV and inflammatory activity, as reflected by the levels of interleukin-6 (IL-6), IL-1 receptor antagonist (IL-1ra) and C-reactive protein (CRP). Subjects and methods. Consecutive women patients who survived hospitalization for acute myocardial infarction, and/or underwent a percutaneous transluminal coronary angioplasty or a coronary artery bypass grafting were included and evaluated in a stable condition 1 year after the index events. An ambulatory 24-h ECG was recorded during normal activities. SDNN index (mean of the standard deviations of all normal to normal intervals for all 5-min segments of the entire recording) and the following frequency domain parameters were assessed: total power, high frequency (HF) power, low frequency (LF) power and very low frequency (VLF) power. Levels of high-sensitivity CRP were measured by nephelometry, IL-6 and IL-1ra concentrations were determined by enzyme immunoassay. Results. Levels of IL-6 showed an inverse relation with HRV measures even after controlling for potential confounding factors. The P-values were 0.02, 0.04, 0.01, 0.03, 0.18 for the multivariate association with SDDN index, total power, VLF power, LF power and HF power respectively. In contrast, the inverse relationship between HRV measures and CRP or IL-1ra levels were weak and nonsignificant. Correlation coefficients for the relationship between IL-6 and HRV measures were both uni- and multivariately higher than for the relationship between HRV measures and any other factors evaluated in this study. Conclusion. Concentration of IL-6 showed a negative, independent association with HRV in women with CHD. Thus, increased inflammatory activity, as reflected by IL-6 levels, may represent a new auxiliary mechanism linking decreased HRV to poor prognosis in CHD.

Place, publisher, year, edition, pages
2004. Vol. 256, no 5, 421-428 p.
Keyword [en]
C-reactive protein, coronary heart disease, heart rate variability, interleukin-1 receptor antagonist, interleukin-6, women
National Category
Medical and Health Sciences
URN: urn:nbn:se:kth:diva-40340DOI: 10.1111/j.1365-2796.2004.01403.xISI: 000224836600008ScopusID: 2-s2.0-7244254581OAI: diva2:441208

QC 20150721

Available from: 2011-09-15 Created: 2011-09-14 Last updated: 2015-07-21Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textScopus

Search in DiVA

By author/editor
Ericson, Mats
By organisation
Ergonomics (Closed 20130701)
In the same journal
Journal of Internal Medicine
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 28 hits
ReferencesLink to record
Permanent link

Direct link