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Interactions Between a Luminescent Conjugated Oligoelectrolyte and Insulin During Early Phases of Amyloid Formation
KTH, School of Engineering Sciences (SCI), Applied Physics, Experimental Biomolecular Physics.
KTH, School of Engineering Sciences (SCI), Applied Physics, Experimental Biomolecular Physics.ORCID iD: 0000-0003-3200-0374
2011 (English)In: Macromolecular Bioscience, ISSN 1616-5187, E-ISSN 1616-5195, Vol. 11, no 8, 1120-1127 p.Article in journal (Refereed) Published
Abstract [en]

Aggregates of misfolded proteins play an important role in diseases such as Alzheimer's. Here it is demonstrated how the anionic oligothiophene p-FTAA interacts with and influences pre-fibrillar protein assemblies during the earlier stages of in vitro fibrillation. Conjugated polythiophenes have previously been demonstrated to detect and discriminate between different types of protein aggregates and also introduce luminescent or conductive properties to these nanoscale fiber structures. Fluorescence spectroscopy, DLS, TEM and FCS are employed to follow the interplay between p-FTAA and insulin during in vitro fibrillation.

Place, publisher, year, edition, pages
2011. Vol. 11, no 8, 1120-1127 p.
Keyword [en]
biofibers, conjugated polymers, fluorescence, light scattering, nanocomposites
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:kth:diva-39515DOI: 10.1002/mabi.201100016ISI: 000294160900011Scopus ID: 2-s2.0-79961044918OAI: oai:DiVA.org:kth-39515DiVA: diva2:442227
Funder
Swedish Research CouncilKnut and Alice Wallenberg Foundation
Available from: 2011-09-20 Created: 2011-09-12 Last updated: 2017-12-08Bibliographically approved

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