Photochemical Surface Functionalization: Synthesis, Nanochemistry and Glycobiological Studies
2011 (English)Doctoral thesis, comprehensive summary (Other academic)
This thesis mainly deals with the development of photochemical approaches to immobilize carbohydrates on surfaces for glycobiological studies. These approaches have been incorporated into a number of state-of-the-art nanobio-platforms, including carbohydrate microarrays, surface plasmon resonance (SPR), quartz crystal microbalance (QCM), atomic force microscopy (AFM), and glyconanomaterials. All the surfaces have displayed good binding capabilities and selectivities after functionalization with carbohydrates, and a range of important data have been obtained concerning surface characteristics and carbohydrate-protein interactions, based on the platforms established. Besides, a variety of non-carbohydrate and carbohydrate-based molecules have been synthesized, during which process the mutarotation of 1-glycosyl thiols and the stereocontrol in 1-S-glycosylation reactions have been thoroughly studied.
Place, publisher, year, edition, pages
Stockholm: KTH Royal Institute of Technology , 2011. , 86 p.
Trita-CHE-Report, ISSN 1654-1081 ; 2011:47
Carbohydrates, Glycobiology, Carbohydrate-protein interactions, Perfluorophenylazide (PFPA), Photochemistry, Carbohydrate surface immobilization, Carbohydrate microarrays, Surface plasmon resonance (SPR), Quartz crystal microbalance (QCM), Atomic force microscopy (AFM), Glyconanomaterials, Concanavalin A (Con A), Cyanovirin-N (CV-N), 1-Glycosyl thiols; Mutarotation, 1-S-glycosylation, Stereocontrol
IdentifiersURN: urn:nbn:se:kth:diva-41973ISBN: 978-91-7501-072-4OAI: oai:DiVA.org:kth-41973DiVA: diva2:445661
2011-10-21, F3, Lindstedtsvägen 26, KTH, Stockholm, 13:00 (English)
Rojo, Javier, Dr.
Ramström, Olof, Professor
QC 201110042011-10-042011-10-042011-10-04Bibliographically approved
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