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Towards a computational methodology for optimizing angioplasty treatments with stenting
KTH, School of Engineering Sciences (SCI), Solid Mechanics (Dept.), Biomechanics.
KTH, School of Engineering Sciences (SCI), Solid Mechanics (Dept.), Biomechanics.
2006 (English)In: Mechanics of Biological TIssue / [ed] Holzapfel, GA; Ogden, RW, 2006, 225-240 p.Conference paper (Refereed)
Abstract [en]

We propose a computational methodology that allows a set of stent parameters to he varied, with the aim of evaluating the difference in the mechanical environment within the wall before and after angioplasty with stenting. Proposed scalar quantities attempt to characterize the wall changes in the form of the contact pressure caused by the stent struts and the stresses within the individual components of the wall caused by the stent. These quantities are derived numerically and serve as indicators. which allow the determination of the correct size and type of the stent for each individual stenosis. In addition, the luminal change due to angioplasty may be computed as well. The methodology is demonstrated by using an image-based three-dimensional geometrical model of a postmortem specimen of a human iliac artery with a stenosis. To describe the material behavior of the artery, we considered mechanical data, of eight different vascular tissues, which formed the stenosis. The constitutive models for the tissue components capture the typical mechanical characteristics under supra-physiological loading conditions. Three-dimensional stent models were parameterized in such a way as to enable new designs to he generated simply with regard to variations in their geometric structure.

Place, publisher, year, edition, pages
2006. 225-240 p.
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URN: urn:nbn:se:kth:diva-42205DOI: 10.1007/3-540-31184-X_16ISI: 000237286900016ScopusID: 2-s2.0-84895246598ISBN: 3-540-25194-4OAI: diva2:446840
IUTAM Symposium on Mechanics of Biological Tissue Location: Graz, Austria, Date: JUN 27-JUL 02, 2004
QC 20111010Available from: 2011-10-10 Created: 2011-10-06 Last updated: 2011-10-10Bibliographically approved

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