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Functionalization of Biomedical Surfaces:  
KTH, School of Chemical Science and Engineering (CHE).
2011 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesisAlternative title
Funktionalisering av biomedicinska ytor (Swedish)
Abstract [en]

Under this project, functionalization of Poly (L-lactic acid) (PLLA) and Poly (ε-caprolactone) (PCL) substrate surfaces with DL- and L- forms of Asparagine and Cysteine is performed.  Poly (L-lactic acid) (PLLA) and Poly (ε-caprolactone) (PCL) substrate surfaces were prepared by solvent casting method from their corresponding pellets. Vapor phase photo grafting technique is implemented to introduce reactive sites. Acrylic acid is a monomer used in presence of Benzophenone initiator. Coupling of DL- and L- forms Asparagine and Cysteine were performed at different reaction conditions. Grafted and coupled surfaces were analyzed for the change in surface chemical composition. Different surface analysis techniques were applied to verify the change in surface properties relative to the bare substrate surfaces. ATR-FTIR was extensively used to analysis functional groups from grafted and coupled surfaces. A change in absorption bands is observed from functionalized surfaces. A reduction in contact angle from ~72° to ~45° for PLLA surfaces and from ~89° to ~55° for PCL surfaces is obtained. The specimens have been sent to department of materials chemistry, Uppsala University, Sweden for XPS analysis and the results are pending. Based on the results obtained from performed tests, functionalization of the substrate surfaces with DL- and L- forms of Asparagine and Cysteine is made possible.

Place, publisher, year, edition, pages
2011. , 44 p.
Keyword [en]
Biomaterials, surfaces, PCL, PLLA, Amino acids
National Category
Polymer Chemistry
Identifiers
URN: urn:nbn:se:kth:diva-42439OAI: oai:DiVA.org:kth-42439DiVA: diva2:446999
Subject / course
Polymer Technology
Educational program
Degree of Master - Materials and Sensors System for Environmental Technologies
Uppsok
Physics, Chemistry, Mathematics
Supervisors
Examiners
Available from: 2011-10-10 Created: 2011-10-10 Last updated: 2011-10-10Bibliographically approved

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