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mGluR-mediated calcium oscillations in the lamprey: a computational model
KTH, Superseded Departments, Numerical Analysis and Computer Science, NADA.
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2004 (English)In: COMPUTATIONAL NEUROSCIENCE: TRENDS IN RESEARCH 2004, AMSTERDAM: ELSEVIER SCIENCE BV , 2004, 431-435 p.Conference paper, Published paper (Refereed)
Abstract [en]

Slow Ca2(+) oscillations caused by release from intracellular stores have been observed in neurons in the lamprey spinal cord. These oscillations are triggered by activation of metabotropic glutamate receptors on the cell surface. The pathway leading from receptor activation to the inositol triphosphate-mediated release of Ca2(+) from the endoplasmatic reticulum has been modelled in order to facilitate further understanding of the nature of these oscillations. The model generates Ca2(+) oscillations with a frequency range of 0.01-0.09 Hz. A prediction of the model is that the frequency will increase with a stronger extracellular glutamate signal.

Place, publisher, year, edition, pages
AMSTERDAM: ELSEVIER SCIENCE BV , 2004. 431-435 p.
Keyword [en]
mGluR5, calcium oscillations, lamprey, spinal cord
National Category
Computer Science
Identifiers
URN: urn:nbn:se:kth:diva-44003ISI: 000223887200064ISBN: 0-444-51649-2 (print)OAI: oai:DiVA.org:kth-44003DiVA: diva2:449100
Conference
12th Annual Computational Neuroscience Meeting (CNS 03). Alicante, SPAIN. JUL 05-09, 2003
Note

QC 20111019

Available from: 2011-10-19 Created: 2011-10-19 Last updated: 2017-06-09Bibliographically approved

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Kotaleski, Jeanette Hällgren

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