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Distensibility in human veins as affected by 5 weeks of repeated elevations of local transmural pressure
KTH, School of Technology and Health (STH), Environmental Physiology.
KTH, School of Technology and Health (STH), Environmental Physiology.
2011 (English)In: European Journal of Applied Physiology, ISSN 1439-6319, E-ISSN 1439-6327, Vol. 111, no 12, 3119-3125 p.Article in journal (Refereed) Published
Abstract [en]

The objectives were to investigate the effects of repeated increments in local intravascular pressure (pressure training; PT) on (1) distensibility in two arm veins, and (2) pain in the arm induced by markedly increased intravascular pressure. Elevation of venous distending pressure (DP) in an arm was induced by placing the subject (n = 8) in a pressure chamber with one arm protruding to the outside via a port in the chamber door, and increasing chamber pressure. During 5 weeks, venous DP in one arm was repeatedly (3 × 40 min/week) increased (65-105 mmHg). Pressure-distension relationships were determined in the brachial and cephalic veins by measuring diameter changes by ultrasonography during stepwise increments in DP to 180 mmHg. In the brachial vein, the diameter change in response to an increase in DP from 30 to 180 mmHg (distensibility) was reduced (P < 0.05) in the pressure-trained arm (11%) compared to that in the control arm before (23%) and after (21%) PT. The cephalic vein showed a similar response with a reduced (P < 0.05) distensibility in the pressure-trained arm (20%) compared to that in the control arm before (29%) and after (25%) PT. At any given DP, arm pain was less (P < 0.05) in the pressure-trained arm than in the control arm before and after PT, presumably reflecting the reduced venous distensibility in the pressure-trained arm. The results support the concept that the distensibility of venous walls adapts to meet the demands imposed by the prevailing local transmural pressures.

Place, publisher, year, edition, pages
2011. Vol. 111, no 12, 3119-3125 p.
Keyword [en]
Venous compliance, G-induced arm pain, Vascular remodeling, Vascular adaptation
National Category
Physiology
Identifiers
URN: urn:nbn:se:kth:diva-44497DOI: 10.1007/s00421-011-1939-7ISI: 000297174800024PubMedID: 21461927Scopus ID: 2-s2.0-84855641495OAI: oai:DiVA.org:kth-44497DiVA: diva2:450709
Note
QC 20111104Available from: 2011-10-21 Created: 2011-10-21 Last updated: 2017-12-08Bibliographically approved
In thesis
1. Distensibility in Arteries, Arterioles and Veins in Humans: Adaptation to Intermittent or Prolonged Change in Regional Intravascular Pressure
Open this publication in new window or tab >>Distensibility in Arteries, Arterioles and Veins in Humans: Adaptation to Intermittent or Prolonged Change in Regional Intravascular Pressure
2010 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The present series of in vivo experiments in healthy subjects, were performed to investigate wall stiffness in peripheral vessels and how this modality adapts to iterative increments or sustained reductions in local intravascular pressures. Vascular stiffness was measured as changes in arterial and venous diameters, and in arterial flow, during graded increments in distending pressures in the vasculature of an arm or a lower leg. In addition, effects of intravascular pressure elevation on flow characteristics in veins, and on limb pain were elucidated. Arteries and veins were stiffer (i.e. pressure distension was less) in the lower leg than in the arm. The pressure-induced increase in arterial flow was substantially greater in the arm than in the lower leg, indicating a greater stiffness in the arterioles of the lower leg. Prolonged reduction of intravascular pressures in the lower body, induced by 5 wks of sustained horizontal bedrest (BR), decreased stiffness in the leg vasculature. BR increased pressure distension in the tibial artery threefold and in the tibial vein by 86 %. The pressure-induced increase in tibial artery flow was greater post bedrest, indicating reduced stiffness in the arterioles of the lower leg. Intermittent increases of intravascular pressures in one arm (pressure training; PT) during a 5-wk period decreased vascular stiffness. Pressure distension and pressure-induced flow in the brachial artery were reduced by about 50 % by PT. PT reduced pressure distension in arm veins by 30 to 50 %. High intravascular pressures changed venous flow to arterial-like pulsatile patterns, reflecting propagation of pulse waves from the arteries to the veins either via the capillary network or through arteriovenous anastomoses. High vascular pressures induced pain, which was aggravated by BR and attenuated by PT; the results suggest that the pain was predominantly caused by vascular overdistension. In conclusion, vascular wall stiffness constitutes a plastic modality that adapts to meet demands imposed by a change in the prevailing local intravascular pressure. That increased intravascular pressure leads to increased arteriolar wall stiffness supports the notion that local pressure load may serve as a “prime mover” in the development of vascular changes in hypertension.

Place, publisher, year, edition, pages
Stockholm: KTH, 2010. 51 p.
Series
Trita-STH : report, ISSN 1653-3836 ; 2010:5
Keyword
arterial stiffness, venous distensibility, venous flow characteristics, bedrest, pressure training
National Category
Physiology
Identifiers
urn:nbn:se:kth:diva-25965 (URN)978-91-7415-778-9 (ISBN)
Public defence
2010-11-26, sal 3:221, Alfreds Nobels Alle 10, Flemingsberg, Huddinge, 09:00 (Swedish)
Opponent
Supervisors
Note
medicine doktorsexamen QC 20101109Available from: 2010-11-09 Created: 2010-11-08 Last updated: 2012-03-20Bibliographically approved

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