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Long-term intermittent hyperoxic exposures do not enhance erythropoiesis
KTH, School of Technology and Health (STH), Environmental Physiology (Closed 20130701).
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2012 (English)In: European Journal of Clinical Investigation, ISSN 0014-2972, E-ISSN 1365-2362, Vol. 42, no 3, 260-265 p.Article in journal (Refereed) Published
Abstract [en]

Eur J Clin Invest 2011 ABSTRACT: Background  Based on a report of a marked increase in the erythropoietin concentration ([EPO]) a few hours after the cessation of a single 2-h session of O(2) breathing, short periods of O(2) administration have been advocated as a therapy for anaemia. Accordingly, the purpose of the present study was to evaluate this theory by investigating the effect of 10 daily short-term exposures to normobaric O(2) over a 2-week period on the plasma [EPO] in healthy individuals. Material and methods  Twenty men were assigned to either an experimental (NBO(2) ) or to a control (AIR) group. The NBO(2) group breathed 100% normobaric O(2) for 2 h every weekday over a 2-week period. The AIR group breathed air within the same time protocol. Blood samples were collected at the pre-, mid- and post-intervention periods to determine [EPO]. Results  [EPO] of the NBO(2) group was significantly lower than that of the AIR group during the mid- and post-periods (P < 0·001). [EPO] of the NBO(2) group showed a slight, albeit statistically nonsignificant, decrease during the mid (∼ 11%)- and post (∼ 16%)-periods. Conclusions  Daily short-term exposures to normobaric hyperoxia do not increase the [EPO] in healthy individuals. The increased O(2) tension suppresses [EPO]. Hence, administration of pure O(2) to enhance erythropoiesis is not warranted.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2012. Vol. 42, no 3, 260-265 p.
Keyword [en]
erythropoietin, hyperoxaemia, ‘normobaric O2 paradox’, oxygen therapy
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URN: urn:nbn:se:kth:diva-44493DOI: 10.1111/j.1365-2362.2011.02578.xISI: 000299832800005PubMedID: 21834800ScopusID: 2-s2.0-84856568775OAI: diva2:450719

QC 20150629

Available from: 2011-10-21 Created: 2011-10-21 Last updated: 2015-06-29Bibliographically approved

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Keramidas, Michail E.Eiken, Ola
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Environmental Physiology (Closed 20130701)
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