Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Effects of motion sickness on thermoregulatory responses in a thermoneutral air environment
KTH, School of Technology and Health (STH), Environmental Physiology.
KTH, School of Technology and Health (STH), Environmental Physiology.
KTH, School of Technology and Health (STH), Environmental Physiology.
2012 (English)In: European Journal of Applied Physiology, ISSN 1439-6319, E-ISSN 1439-6327, Vol. 112, no 5, 1717-1723 p.Article in journal (Refereed) Published
Abstract [en]

Motion sickness (MS) has been identified as a non-thermal factor that can moderate autonomic thermoregulatory responses. It has been shown that MS exaggerates core cooling during immersion in cold (15A degrees C) and luke-warm (28A degrees C) water by attenuating cold-induced vasoconstriction. The aim of the present study was to investigate whether MS affects thermal balance in a thermoneutral air environment. Eleven subjects were exposed to rotation in two conditions, control (CN) and MS. In the CN condition subjects refrained from head movements, whereas in the MS condition they performed a sequence of maximal head movements (left, right, up, down) at 15-s intervals until they were very nauseous. Sweating rate, rectal temperature (T (re)), the difference in temperature between the right forearm and tip of the second finger (T (ff)) as an index of cutaneous vasomotor tone, perceived MS, thermal comfort and temperature perception were recorded before and during rotation, and during 90-min post-rotation. During the post-rotation period, T (re) dropped and sweating rate increased in the MS but not in the CN condition. The T (ff) response suggests that MS-induced peripheral vasodilatation which, together with the sweating resulted in increased heat loss. During rotation, subjects perceived temperature to be uncomfortably high, suggesting that MS may also affect thermoregulatory behaviour. It thus appears that also in a thermoneutral air environment MS may substantially affect thermal balance.

Place, publisher, year, edition, pages
2012. Vol. 112, no 5, 1717-1723 p.
Keyword [en]
Motion sickness, Behavioural thermoregulation, Vasomotor tone, Sweating
National Category
Physiology
Identifiers
URN: urn:nbn:se:kth:diva-44492DOI: 10.1007/s00421-011-2142-6ISI: 000302745700015PubMedID: 21892631Scopus ID: 2-s2.0-84861526308OAI: oai:DiVA.org:kth-44492DiVA: diva2:450724
Note

QC 20120525

Available from: 2011-10-21 Created: 2011-10-21 Last updated: 2017-12-08Bibliographically approved
In thesis
1. Effects of Motion Sickness on Human Thermoregulatory Mechanisms
Open this publication in new window or tab >>Effects of Motion Sickness on Human Thermoregulatory Mechanisms
2010 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The presented studies were performed to investigate the effects of motion sickness (MS) on human autonomic and behavioural thermoregulatory mechanisms during cold stress and in a thermoneutral environment. The roles of histaminergic and cholinergic neuron systems in autonomic thermoregulation and MS-dependent dysfunction of autonomic thermoregulation were studied using a histamine-receptor blocker, dimenhydrinate (DMH), and a muscarine-receptor blocker, scopolamine (Scop). In addition, the effects of these substances on MS-induced nausea and perceptual thermoregulatory responses were studied. MS was found to lower core temperature, during cold stress by attenuation of cold-induced vasoconstriction and decreased shivering thermogenesis, and in a thermoneutral environment by inducing sweating and vasodilatation. The increased core cooling during cold stress was counteracted by DMH but not by Scop. In a thermoneutral environment, the temperature was perceived as uncomfortably warm during and after the MS provocation despite decreases in both core and skin temperature. No such effect was seen during cold-water immersion. Both pharmacologic substances had per se different effects on autonomic thermoregulatory responses during cold stress. Scop decreased heat preservation, but did not affect core cooling, while DMH reduced the rate of core cooling through increased shivering thermogenesis. Both DMH and Scop per se decreased thermal discomfort during cold-water immersion.Findings support the notion of modulating roles of histamine (H) and acetylcholine (Ach) in autonomic thermoregulation and during MS. MS activates cholinergic and histaminergic pathways, thereby increasing the levels of H and Ach in several neuro-anatomical structures. As a secondary effect, MS also elevates blood levels of several neuropeptides, which in turn would influence central and/or peripheral thermoregulatory responses.In conclusion, MS may predispose to hypothermia, by impairment of autonomic thermoregulation in both cold and thermoneutral environments and by modulation of behavioural thermoregulatory input signals. This might have significant implications for survival in maritime accidents.

Place, publisher, year, edition, pages
Stockholm: KTH, 2010. v, 41 p.
Series
Trita-STH : report, ISSN 1653-3836 ; 2010:6
Keyword
Motion Sickness, autonomic thermoregulation, behavioural thermoregulation, hypothermia, acetylcholine, histamine
National Category
Physiology
Identifiers
urn:nbn:se:kth:diva-26058 (URN)978-91-7415-795-6 (ISBN)
Public defence
2010-12-10, sal 3:221, Alfred Nobels alle 10, Huddinge, 13:30 (English)
Opponent
Supervisors
Note

Medicine doktorsexamen

Available from: 2010-11-23 Created: 2010-11-11 Last updated: 2013-06-05Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedScopus

Search in DiVA

By author/editor
Nobel, GerardTribukait, ArneEiken, Ola
By organisation
Environmental Physiology
In the same journal
European Journal of Applied Physiology
Physiology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 1120 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf