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An integrated fluido-chemical model towards modeling the formation of intra-luminal thrombus in abdominal aortic aneurysms
KTH, School of Engineering Sciences (SCI), Solid Mechanics (Dept.).
Mechanics Division, National Institute of Metrological Research (INRiM), Turin, Italy.
KTH, School of Engineering Sciences (SCI), Solid Mechanics (Dept.).
2011 (English)Article in journal (Other academic) Submitted
Abstract [en]

Abdominal Aortic Aneurysms (AAAs) are frequently characterized by the presence of an Intra-Luminal Thrombus (ILT) known to influence biochemically and biomechanically their evolution. ILT progression mechanism is still unclear and little is known regarding the impact of chemicals transported by blood flow. It is expected that chemical agonists and antagonists of platelets activation, aggregation, and adhesion play an important role in ILT development. Starting fromthis assumption, the evolution of chemical species related to the coagulation cascade (CC), their relation to coherent vortical structures (VSs) and their effect on ILT evolution have been studied. To this end a fluido-chemical model that simulates the CC through a series of convection-diffusion-reaction (CDR) equations and considers blood as a non-Newtonian incompressible fluid has been developed. In addition to the relation between VSs and thrombin distribution, high thrombin concentrations at the distal portion of the AAA were observed, i.e. the region where the thickest ILT is usually seen. The proposed model, due to its ability to couple the fluid and chemical domains, provides an integrated mechanochemical picture that potentially could unveil mechanisms of ILT formation and development.

Place, publisher, year, edition, pages
2011.
National Category
Medical Engineering
Identifiers
URN: urn:nbn:se:kth:diva-44536OAI: oai:DiVA.org:kth-44536DiVA: diva2:451011
Note
QS 20120316Available from: 2011-10-24 Created: 2011-10-24 Last updated: 2012-03-16Bibliographically approved
In thesis
1. On the interplay between hemodynamics and biochemsitry of the normal and aneurysmatic abdominal aorta
Open this publication in new window or tab >>On the interplay between hemodynamics and biochemsitry of the normal and aneurysmatic abdominal aorta
2011 (English)Licentiate thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Stockholm: KTH Royal Institute of Technology, 2011. vii p.
Series
Trita-HFL. Report / Royal Institute of Technology, Solid Mechanics, ISSN 1654-1472 ; 0512
National Category
Medical Engineering
Identifiers
urn:nbn:se:kth:diva-44538 (URN)978-91-7501-139-4 (ISBN)
Presentation
2011-10-14, Sal D41, KTH, Lindstedtvägen 17, Stockholm, 10:15
Opponent
Supervisors
Note

QC 20111024

Available from: 2011-10-24 Created: 2011-10-24 Last updated: 2013-01-15Bibliographically approved

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CiteExportLink to record
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  • apa
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