An integrated fluido-chemical model towards modeling the formation of intra-luminal thrombus in abdominal aortic aneurysms
2011 (English)Article in journal (Other academic) Submitted
Abdominal Aortic Aneurysms (AAAs) are frequently characterized by the presence of an Intra-Luminal Thrombus (ILT) known to influence biochemically and biomechanically their evolution. ILT progression mechanism is still unclear and little is known regarding the impact of chemicals transported by blood flow. It is expected that chemical agonists and antagonists of platelets activation, aggregation, and adhesion play an important role in ILT development. Starting fromthis assumption, the evolution of chemical species related to the coagulation cascade (CC), their relation to coherent vortical structures (VSs) and their effect on ILT evolution have been studied. To this end a fluido-chemical model that simulates the CC through a series of convection-diffusion-reaction (CDR) equations and considers blood as a non-Newtonian incompressible fluid has been developed. In addition to the relation between VSs and thrombin distribution, high thrombin concentrations at the distal portion of the AAA were observed, i.e. the region where the thickest ILT is usually seen. The proposed model, due to its ability to couple the fluid and chemical domains, provides an integrated mechanochemical picture that potentially could unveil mechanisms of ILT formation and development.
Place, publisher, year, edition, pages
IdentifiersURN: urn:nbn:se:kth:diva-44536OAI: oai:DiVA.org:kth-44536DiVA: diva2:451011
QS 201203162011-10-242011-10-242012-03-16Bibliographically approved