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Effect of nitrous oxide on human skeletal muscle function
Karolinska Institutet.
1996 (English)In: Acta Anaesthesiologica Scandinavica, ISSN 0001-5172, E-ISSN 1399-6576, Vol. 40, no 4, 486-488 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Nitrous oxide (N2O) is commonly administered in conjunction with parturition, which requires the performance of repeated high-force voluntary muscle actions. Therefore, we examined the effect of a subanesthetic dose of N2O on the force-velocity relationship of the quadriceps femoris muscle.

METHODS: Nine healthy subjects performed maximal voluntary muscle actions once while breathing air and once while breathing a normoxic gas mixture containing 35% (N2O). Peak torque of the knee extensors was measured during concentric muscle contractions at different angular velocities (30, 60, 90, 150 and 210 degrees s-1), and eccentric (30, 60, 90, and 150 degrees s-1) and isometric (knee-joint angle approximately equal to 60 degrees) muscle actions. Maximal angular velocity was determined during unloaded knee extensions.

RESULTS: N2O decreased peak torque at any given angular velocity. The overall decrease in peak averaged 4.8 +/- 2.2% (P < 0.0001). Likewise, N2O decreased maximal angular velocity by 5.7 +/- 4.3% (P < 0.01). Thus, the impairment in muscle function induced by a 35% N2O is only minute and hence most likely of little significance in clinical practice.

Place, publisher, year, edition, pages
1996. Vol. 40, no 4, 486-488 p.
Keyword [en]
Force-velocity relationship, muscle strength, N2O, physical performance
National Category
URN: urn:nbn:se:kth:diva-44613DOI: 10.1111/j.1399-6576.1996.tb04473.xISI: A1996UL11100015PubMedID: 8738695OAI: diva2:452008
QC 20111103Available from: 2011-10-27 Created: 2011-10-25 Last updated: 2011-11-03Bibliographically approved

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Eiken, Ola
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