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Effects of blood-volume distribution on the characteristics of the carotid baroreflex in humans at rest and during exercise
Karolinska Institutet.
1994 (English)In: Acta Physiologica Scandinavica, ISSN 0001-6772, E-ISSN 1365-201X, Vol. 150, no 1, 89-94 p.Article in journal (Refereed) Published
Abstract [en]

Seven supine subjects were studied at rest and during mild to moderate dynamic leg exercise with and without unloading of the cardiopulmonary baroreceptors accomplished by exposing the lower portion of the body to a subatmospheric pressure of 20 mmHg (Lower Body Negative Pressure, LBNP). The function of the cardiac branch of the carotid baroreflex was studied over its full operational range by measuring R-R intervals during application of pulse synchronous graded pressures (40 to -65 mmHg) in a neck-chamber device. Raising the carotid transmural pressure (systolic arterial pressure minus neck-chamber pressure) induced increasing R-R intervals in all conditions. In conformity with previous results from our laboratories it was found that the maximal rate of change in relative R-R intervals and the corresponding transmural pressure were higher during exercise than at rest, indicating that exercise increased the carotid baroreflex sensitivity and shifted its optimal buffering range to higher arterial pressures. LBNP did not affect the characteristics of the reflex at rest nor during exercise. It is concluded that reduced central venous pressure with consequent selective cardiopulmonary receptor disengagement exerts no influence on the carotid baroreflex control of heart rate (HR), as tested over the entire arterial pressure-effector response relation, either at rest or during mild-moderate exercise.

Place, publisher, year, edition, pages
1994. Vol. 150, no 1, 89-94 p.
Keyword [en]
arterial baroreflex, baroreceptor interaction, exercise, pressure-response relation
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URN: urn:nbn:se:kth:diva-44619DOI: 10.1111/j.1748-1716.1994.tb09663.xISI: A1994MP26300011PubMedID: 8135126OAI: diva2:452035
QC 20111103Available from: 2011-10-27 Created: 2011-10-25 Last updated: 2011-11-03Bibliographically approved

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Eiken, Ola
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