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Venous gas emboli and exhaled nitric oxide with simulated and actual extravehicular activity
Swedish Defence Research Agency.
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2009 (English)In: Respiratory Physiology & Neurobiology, ISSN 1569-9048, E-ISSN 1878-1519, Vol. 169, S59-S62 p.Article in journal (Refereed) Published
Abstract [en]

The decompression experienced due to the change in pressure from a space vehicle (1013hPa) to that in a suit for extravehicular activity (EVA) (386hPa) was simulated using a hypobaric chamber. Previous ground-based research has indicated around a 50% occurrence of both venous gas emboli (VGE) and symptoms of decompression illness (DCI) after similar decompressions. In contrast, no DCI symptoms have been reported from past or current space activities. Twenty subjects were studied using Doppler ultrasound to detect any VGE during decompression to 386hPa, where they remained for up to 6h. Subjects were supine to simulate weightlessness. A large number of VGE were found in one subject at rest, who had a recent arm fracture; a small number of VGE were found in another subject during provocation with calf contractions. No changes in exhaled nitric oxide were found that can be related to either simulated EVA or actual EVA (studied in a parallel study on four cosmonauts). We conclude that weightlessness appears to be protective against DCI and that exhaled NO is not likely to be useful to monitor VGE.

Place, publisher, year, edition, pages
2009. Vol. 169, S59-S62 p.
Keyword [en]
Altitude, Decompression sickness, Simulated microgravity, Space vehicle, Ultrasound Doppler
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URN: urn:nbn:se:kth:diva-45323DOI: 10.1016/j.resp.2009.04.003ISI: 000271846300017PubMedID: 19442591OAI: diva2:452258
QC 20111114Available from: 2011-10-28 Created: 2011-10-28 Last updated: 2011-11-14Bibliographically approved

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Gennser, Mikael
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