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Erythropoietin concentrations during 10 days of normobaric hypoxia under controlled environmental circumstances.
Swedish Defence Research Agency.
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2002 (English)In: Acta Physiologica Scandinavica, ISSN 0001-6772, E-ISSN 1365-201X, Vol. 174, no 3, 225-229 p.Article in journal (Refereed) Published
Abstract [en]

Serum erythropoietin levels (s-[epo]), haemoglobin concentration ([Hb]), haematocrit (hct), and ferritin concentration ([fer]) were measured in seven healthy male volunteers (20-23 years) exposed continuously to hypoxia (PO(2) 14 kPa) for 10 days. Serum erythropoietin concentration increased significantly from 9.5 +/- 3.51 to 33.6 +/- 11.64 U L(-1) (P < 0.05) after 2 days of hypoxia. Thereafter, s-[epo] decreased. However, after 10 days s-[epo] was 18.7 +/- 5.83 U L(-1) which was still increased above the pre-hypoxia level (P < 0.05). Serum haemoglobin concentration and hct increased over the 10 days of hypoxia, [Hb] from 152 +/- 8.9 to 168 +/- 9.2 gL(-1) (P < 0.001), and hct from 43 +/- 2.4 to 49 +/- 2.6% (P < 0.001). Ferritin concentration decreased significantly during the hypoxic exposure from 82 +/- 46.9 to 44 +/- 31.7 mmol L(-1) after 10 days (P < 0.01). In conclusion, the initial increase of s-[epo] under controlled normobaric hypoxia was marked, 353%, and levelled off after 5-10 days at 62-97% above normoxia level. There was also a significant increase in [Hb] and hct and a decrease in [fer] after 10 days of exposure to normobaric hypoxia.

Place, publisher, year, edition, pages
2002. Vol. 174, no 3, 225-229 p.
Keyword [en]
altitude training, doping, erythropoietin, hypoxia
National Category
Physiology
Identifiers
URN: urn:nbn:se:kth:diva-45335DOI: 10.1046/j.1365-201x.2002.00940.xISI: 000174423200003PubMedID: 11906321OAI: oai:DiVA.org:kth-45335DiVA: diva2:452351
Note
QC 20111109Available from: 2011-10-28 Created: 2011-10-28 Last updated: 2017-12-08Bibliographically approved

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