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An integrated approach to biodistribution radiation absorbed dose estimates
New York University.
New York University.
Columbia University, Department of Computer Science.ORCID iD: 0000-0002-6066-746X
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1993 (English)In: European Journal of Nuclear Medicine, ISSN 0340-6997, E-ISSN 1432-105x, Vol. 20, no 2, 165-169 p.Article in journal (Refereed) Published
Abstract [en]

An integrated approach to existing methods of extracting biodistribution data, pharmacokinetics and radiation absorbed dose estimates from serial scintigraphic images is described. This approach employs a single computer-generated user interface to reformat planar scans into a standard file type, align conjugate (anterior and posterior) images, draw regions of interest {(ROIs)} over selected organs and lesions and generate count data for anterior and posterior views and calculated geometric means. Using standard correction methods, the fraction injected activity is obtained for all {ROIs} and total body. This methodology has been applied to the analysis of {indium-III-labelled} breast-cancer-directed antibodies and technetium-90m-labelled {CEA-specific} antibody fragments in non-small-cell lung cancer. It is anticipated that this approach will be useful for evaluating the dosimetry of other radiolabelled monoclonal antibodies, as well as other radiopharmaceuticals.}

Place, publisher, year, edition, pages
1993. Vol. 20, no 2, 165-169 p.
Keyword [en]
Breast Neoplasms, Carcinoma, {Non-Small-Cell} Lung, Female, Humans, Image Processing, {Computer-Assisted}, Lung Neoplasms, Male, Radiation Dosage, Radioimmunodetection, Radiometry, Tissue Distribution
National Category
Medical and Health Sciences
Research subject
URN: urn:nbn:se:kth:diva-46755ISI: A1993KK84300013PubMedID: 8382614OAI: diva2:454137
QC 20111107Available from: 2011-11-05 Created: 2011-11-05 Last updated: 2013-09-09Bibliographically approved

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Maguire Jr., Gerald Q.
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