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CT-SPECT fusion to correlate radiolabeled monoclonal antibody uptake with abdominal CT findings
New York University.
New York University.
New York University.
New York University.
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1989 (English)In: Radiology, ISSN 0033-8419, E-ISSN 1527-1315, Vol. 172, no 3, 861-865 p.Article in journal (Refereed) Published
Abstract [en]

To enhance the information provided by computed tomography {(CT)} and single photon emission computed tomography {(SPECT)} performed with radiolabeled, anti-carcinoembryonic antigen monoclonal antibody {(MoAb)}, the authors performed fusion of these types of images from eight subjects with suspected colorectal adenocarcinoma. Section thickness and pixel size of the two studies were matched, coordinates of corresponding points from each study were identified, and {CT} sections were translated, rotated, and reprojected to match the corresponding {SPECT} scans. The {CT-SPECT} fusion enabled identification of anatomic sites of tumor-specific {MoAb} accumulation in four cases, showed non-specific {MoAb} accumulation in two, and helped confirm information only suggested by the two studies separately in one.

Place, publisher, year, edition, pages
American College of Radiology , 1989. Vol. 172, no 3, 861-865 p.
Keyword [en]
Adenocarcinoma, Antibodies, Monoclonal, Carcinoembryonic Antigen, Colorectal Neoplasms, Female, Humans, Image Processing, {Computer-Assisted}, Indium Radioisotopes, Male, Tomography, {Emission-Computed}, Tomography, {X-Ray} Computed
National Category
Radiology, Nuclear Medicine and Medical Imaging
Research subject
SRA - ICT
Identifiers
URN: urn:nbn:se:kth:diva-46782ISI: A1989AM01500060OAI: oai:DiVA.org:kth-46782DiVA: diva2:454183
Note
QC 20111107. PMID: 2788895Available from: 2011-11-06 Created: 2011-11-06 Last updated: 2017-12-08Bibliographically approved

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Maguire Jr., Gerald Q.

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