Minor Enantiomer Recycling-Effect of Two Reinforcing Catalysts on Product Yield and Enantiomeric Excess
2010 (English)In: ChemCatChem, ISSN 1867-3880, Vol. 2, no 6, 683-693 p.Article in journal (Refereed) Published
Kinetic modeling of a recycling procedure in which the minor product enantiomer from an enantioselective catalytic reaction is selectively retransformed to starting material by a second chiral catalyst demonstrates that the enantiomeric excess of the product is not affected by the relative amounts of the two catalysts, but that the yield increases when the amount of the catalyst for the product-forming reaction is increased. The yield, but not the enantiomeric excess, is also affected by the initial substrate concentration. The recycling process is compared to sequential processes in which either the second catalyst is added after completion of the first reaction or in which the two catalysts are added simultaneously. In the sequential processes, high enantioselectivity can be obtained at the expense of product yield, whereas under recycling conditions both high enantiomeric excess and high yield can be achieved. Experimental data from a recycling procedure providing qualitative support for results from kinetic modeling are presented.
Place, publisher, year, edition, pages
2010. Vol. 2, no 6, 683-693 p.
asymmetric catalysis, biocatalysis, enantioselectivity, kinetic modeling, metal catalyst
IdentifiersURN: urn:nbn:se:kth:diva-46653DOI: 10.1002/cctc.200900327ISI: 000279479100016ScopusID: 2-s2.0-79957822367OAI: oai:DiVA.org:kth-46653DiVA: diva2:454680
FunderSwedish Research CouncilKnut and Alice Wallenberg Foundation
QC 201111082011-11-082011-11-042014-12-02Bibliographically approved