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Membrane topology of the Drosophila OR83b odorant receptor
Stockholm Bioinformatics Center, AlbaNova.ORCID iD: 0000-0001-5689-9797
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2007 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 581, no 29, 5601-5604 p.Article in journal (Refereed) Published
Abstract [en]

By analogy to mammals, odorant receptors (ORs) in insects, such as Drosophila melanogaster, have long been thought to belong to the G-protein coupled receptor (GPCR) superfamily. However, recent work has cast doubt on this assumption and has tentatively suggested an inverted topology compared to the canonical N(out) - C(in) 7 transmembrane (TM) GPCR topology, at least for some Drosophila ORs. Here, we report a detailed topology mapping of the Drosophila OR83b receptor using engineered glycosylation sites as topology markers. Our results are inconsistent with a classical GPCR topology and show that OR83b has an intracellular N-terminus, an extracellular C-terminus, and 7TM helices.

Place, publisher, year, edition, pages
2007. Vol. 581, no 29, 5601-5604 p.
Keyword [en]
Drosophila melanogaster, Membrane protein, Odorant receptor, Topology
National Category
Bioinformatics (Computational Biology)
URN: urn:nbn:se:kth:diva-48857DOI: 10.1016/j.febslet.2007.11.007ISI: 000253488000010PubMedID: 18005664OAI: diva2:458742
QC 20111124Available from: 2011-11-23 Created: 2011-11-23 Last updated: 2011-11-24Bibliographically approved

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Käll, Lukas
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