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BEYOND PDMS:: OFF-STOCHIOMETRY THIOL-ENE BASED SOFT LITHOGRAPHY FOR RAPID PROTOTYPING OF MICROFLUIDIC DEVICES
KTH, School of Electrical Engineering (EES), Microsystem Technology (Changed name 20121201).
KTH, School of Electrical Engineering (EES), Microsystem Technology (Changed name 20121201).ORCID iD: 0000-0002-0441-6893
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.ORCID iD: 0000-0002-9200-8004
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2010 (English)In: 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences (micro TAS 2010), 2010, 70-72 p.Conference paper, Published paper (Refereed)
Abstract [en]

We present an easy to use, rapid fabrication platform for microfluidic systems, based on micro-molding of novel thiolene based polymer formulations. The novel fabrication platform addresses major drawbacks of PDMS by allowing large freedom in material and surface properties, including: (photo)patterning of stable surface modifications, bonding without plasma treatment, rapid UV or thermal curing, variable E-modulus, minimized leaching of uncured components [1] and suppressed non-specific binding of biomolecules [2]. This process is potentially suited for both rapid prototyping in the laboratory and medium-scale commercial production, bridging the “development gap”.

Place, publisher, year, edition, pages
2010. 70-72 p.
Keyword [en]
Click chemistry, Soft lithography, Thiol-ene
National Category
Other Electrical Engineering, Electronic Engineering, Information Engineering Polymer Technologies Polymer Chemistry
Identifiers
URN: urn:nbn:se:kth:diva-49437Scopus ID: 2-s2.0-84883815123ISBN: 978-161839062-2 (print)OAI: oai:DiVA.org:kth-49437DiVA: diva2:459656
Conference
14th International Conference on Miniaturized Systems for Chemistry and Life Sciences (micro TAS 2010), Groningen, Netherlands, 3-7 Oct, 2010
Projects
Intopsens
Note

QC 20140819

Available from: 2011-11-27 Created: 2011-11-27 Last updated: 2015-06-18Bibliographically approved
In thesis
1. Advanced polymeric scaffolds for functional materials in biomedical applications
Open this publication in new window or tab >>Advanced polymeric scaffolds for functional materials in biomedical applications
2014 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Advancements in the biomedical field are driven by the design of novel materials with controlled physical and bio-interactive properties. To develop such materials, researchers rely on the use of highly efficient reactions for the assembly of advanced polymeric scaffolds that meet the demands of a functional biomaterial. In this thesis two main strategies for such materials have been explored; these include the use of off-stoichiometric thiol-ene networks and dendritic polymer scaffolds. In the first case, the highly efficient UV-induced thiol-ene coupling (TEC) reaction was used to create crosslinked polymeric networks with a predetermined and tunable excess of thiol or ene functionality. These materials rely on the use of readily available commercial monomers. By adopting standard molding techniques and simple TEC surface modifications, patterned surfaces with tunable hydrophobicity could be obtained. Moreover, these materials are shown to have great potential for rapid prototyping of microfluidic devices. In the second case, dendritic polymer scaffolds were evaluated for their ability to increase surface interactions and produce functional 3D networks. More specifically, a self-assembled dendritic monolayer approach was explored for producing highly functional dendronized surfaces with specific interactions towards pathogenic E. coli bacteria. Furthermore, a library of heterofunctional dendritic scaffolds, with a controllable and exact number of dual-purpose azide and ene functional groups, has been synthesized. These scaffolds were explored for the production of cell interactive hydrogels and primers for bone adhesive implants. Dendritic hydrogels decorated with a selection of bio-relevant moieties and with Young’s moduli in the same range as several body tissues could be produced by facile UV-induced TEC crosslinking. These gels showed low cytotoxic response and relatively rapid rates of degradation when cultured with normal human dermal fibroblast cells. When used as primers for bone adhesive patches, heterofunctional dendrimers with high azide-group content led to a significant increase in the adhesion between a UV-cured hydrophobic matrix and the wet bone surface (compared to patches without primers).

Place, publisher, year, edition, pages
Stockholm: KTH Royal Institute of Technology, 2014. 72 p.
Series
TRITA-CHE-Report, ISSN 1654-1081 ; 2014:1
Keyword
Dendrimer, hydrogel, PEG, dendritic monolayers, thiol-ene networks, off-stochiometric
National Category
Polymer Technologies Medical Materials Materials Chemistry Polymer Chemistry
Identifiers
urn:nbn:se:kth:diva-139944 (URN)978-91-7501-978-9 (ISBN)
Public defence
2014-01-31, F3, Lindstedtsvägen 26, KTH, Stockholm, 10:00 (English)
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Note

QC 20140116

Available from: 2014-01-16 Created: 2014-01-15 Last updated: 2014-01-16Bibliographically approved

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Haraldsson, TommyMalkoch, Michaelvan der Wijngaart, Wouter

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