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Unmasking true signal/tumor information from ProstaScint scans
New York University.
New York University.
New York University.
KTH, Superseded Departments, Microelectronics and Information Technology, IMIT. (Computer Communications)ORCID iD: 0000-0002-6066-746X
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2004 (English)In: MEDICAL IMAGING 2004: IMAGE PROCESSING, PTS 1-3 / [ed] Fitzpatrick, JM; Sonka, M, SPIE - International Society for Optical Engineering, 2004, Vol. 5370, 1980-1990 p.Conference paper (Refereed)
Abstract [en]

Purpose: Improve tumor localization in In-111 ProstaScint SPECT scans through improved reconstruction and identification/removal of non-specific blood pool volumes using simultaneously acquired Tc-99m tagged red blood cell (RBC) SPECT scans. Methods: We chose 30 patients with a history of prostate cancer who had undergone CT/MR and simultaneous Tc-99m RBC/In-111 ProstaScint SPECT scans due to rising PSA. To estimate the impact of reconstruction methods on anatomic definition and artifacts, SPECT volume data sets were reconstructed using ordered set-expectation maximization (OS-EM) with varying numbers of iterations and subsets, and these were compared against each other and against standard filtered back projection (FBP) reconstruction. Non-blood pool bladder activity in the Tc-99m scans was suppressed prior to subtraction from the In-111 scans by using an averaging algorithm within an ellipsoid volume encompassing the bladder. Outside the ellipsoid volume, Tc-99m voxel values were subtracted from the corresponding In-111 voxels after normalization of the data sets based on peak activity within the descending aorta. Results: OS-EM reconstruction using 3 iterations and 45 subsets showed improved representation of anatomy compared with FBP. Bladder suppression reduced artifacts in the prostate bed. The subtraction method reduced the blood pool signal, confirmed visually by superimposition with matched CT/MR scans. Conclusions: OS-EM reconstruction together with bladder suppression and subtraction of the blood pool may help improve the specificity of ProstaScint SPECT interpretation and increase its utility in radiation therapy treatment planning.

Place, publisher, year, edition, pages
SPIE - International Society for Optical Engineering, 2004. Vol. 5370, 1980-1990 p.
, Proceedings Of The Society Of Photo-Optical Instrumentation Engineers (SPIE), ISSN 0277-786X ; 5370
Keyword [en]
ProstaScint, reconstruction algorithms, artifact elimination, volume fusion, volume subtraction, prostate cancer treatment planning
National Category
Radiology, Nuclear Medicine and Medical Imaging
Research subject
URN: urn:nbn:se:kth:diva-50117DOI: 10.1117/12.534737ISI: 000222378600216ScopusID: 2-s2.0-5644248150ISBN: 0-8194-5283-1OAI: diva2:461064
Medical Imaging 2004 Conference Location: San Diego, CA Date: FEB 17-19, 2004
QC 20111205Available from: 2011-12-02 Created: 2011-12-02 Last updated: 2013-09-09Bibliographically approved

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Maguire Jr., Gerald Q.
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