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Comparison and evaluation of retrospective intermodality image registration techniques
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1997 (English)In: SPIE - The International Society for Optical Engineering, SPIE - International Society for Optical Engineering, 1997, Vol. 2710, 332-347 p.Conference paper (Refereed)
Abstract [en]

All retrospective image registration methods have attached to them some intrinsic estimate of registration error. However, this estimate of accuracy may not always be a good indicator of the distance between actual and estimated positions of targets within the cranial cavity. This paper describes a project whose principal goal is to use a prospective method based on fiducial markers as a ’gold standard’ to perform an objective, blinded evaluation of the accuracy of several retrospective image-to-image registration techniques. Image volumes of three modalities – CT, MR, and PET – were taken of patients undergoing neurosurgery at Vanderbilt University Medical Center. These volumes had all traces of the fiducial markers removed, and were provided to project collaborators outside Vanderbilt, who then performed retrospective registrations on the volumes, calculating transformations from CT to MR and/or from PET to MR, and communicated their transformations to Vanderbilt where the accuracy of each registration was evaluated. In this evaluation the accuracy is measured at multiple ’regions of interest,’ i.e. areas in the brain which would commonly be areas of neurological interest. A region is defined in the MR image and its centroid C is determined. Then the prospective registration is used to obtain the corresponding point C’ in CT or PET. To this point the retrospective registration is then applied, producing C’ in MR. Statistics are gathered on the target registration error (TRE), which is the disparity between the original point C and its corresponding point C’. A second goal of the project is to evaluate the importance of correcting geometrical distortion in MR images, by comparing the retrospective TRE in the rectified images, i.e., those which have had the distortion correction applied, with that of the same images before rectification. This paper presents preliminary results of this study along with a brief description of each registration technique and an estimate of both preparation and execution time needed to perform the registration.

Place, publisher, year, edition, pages
SPIE - International Society for Optical Engineering, 1997. Vol. 2710, 332-347 p.
Keyword [en]
Brain, Computer Communication Networks, Diagnostic Errors, Humans, Magnetic Resonance Imaging, Observer Variation, Prospective Studies, Retrospective Studies, Sensitivity and Specificity, Teleradiology, Tomography, Emission-Computed, Tomography, X-Ray Computed
National Category
Radiology, Nuclear Medicine and Medical Imaging
Research subject
URN: urn:nbn:se:kth:diva-50230DOI: 10.1117/12.237936OAI: diva2:461348
Medical Imaging 1996 Image Processing. Newport Beach, CA. 12 February 1996 - 15 February 1996
QC 20111205Available from: 2011-12-02 Created: 2011-12-02 Last updated: 2013-09-09Bibliographically approved

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Maguire Jr., Gerald Q.
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Radiology, Nuclear Medicine and Medical Imaging

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