Change search
ReferencesLink to record
Permanent link

Direct link
The Feedback Control of Glucose: On the road to type II diabetes
KTH, School of Electrical Engineering (EES), Electric Power Systems.
Texas Tech University.
2006 (English)In: Proceedings of the 45th IEEE Conference on Decision & Control, 2006, 685-690 p.Conference paper (Refereed)
Abstract [en]

This paper develops a mathematical model for the feedback control of glucose regulation in the healthy human being and is based on the work of Sorensen (1985). The proposed model serves as a starting point for modeling type H diabetes. Four agents - glucose and the three hormones insulin, glucagon, and incretins - are assumed to have an effect on glucose metabolism. By letting compartments represent anatomical organs, the model has a close resemblance to a real human body. Mass balance equations that account for blood flows, exchange between compartments, and metabolic sinks and sources are written, and these result in simultaneous differential equations that are solved numerically. The metabolic sinks and sources - removing or adding glucose, insulin, glucagon, and incretins - describe physiological processes in the body. These processes function as feedback control systems and have nonlinear behaviors. The results of simulations performed for three different clinical test types indicate that the model is successful in simulating intravenous glucose, oral glucose, and meals containing mainly carbohydrates.

Place, publisher, year, edition, pages
2006. 685-690 p.
, IEEE Conference on Decision and Control, ISSN 0191-2216
National Category
Other Mathematics
URN: urn:nbn:se:kth:diva-50394DOI: 10.1109/CDC.2006.377192ISI: 000252251600071ISBN: 978-1-4244-0170-3OAI: diva2:461744
45th IEEE Conference on Decision and Control Location: San Diego, CA Date: DEC 13-15, 2006
QC 20111206Available from: 2011-12-05 Created: 2011-12-05 Last updated: 2011-12-06Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Alvehag, Karin
By organisation
Electric Power Systems
Other Mathematics

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 109 hits
ReferencesLink to record
Permanent link

Direct link