The Feedback Control of Glucose: On the road to type II diabetes
2006 (English)In: Proceedings of the 45th IEEE Conference on Decision & Control, 2006, 685-690 p.Conference paper (Refereed)
This paper develops a mathematical model for the feedback control of glucose regulation in the healthy human being and is based on the work of Sorensen (1985). The proposed model serves as a starting point for modeling type H diabetes. Four agents - glucose and the three hormones insulin, glucagon, and incretins - are assumed to have an effect on glucose metabolism. By letting compartments represent anatomical organs, the model has a close resemblance to a real human body. Mass balance equations that account for blood flows, exchange between compartments, and metabolic sinks and sources are written, and these result in simultaneous differential equations that are solved numerically. The metabolic sinks and sources - removing or adding glucose, insulin, glucagon, and incretins - describe physiological processes in the body. These processes function as feedback control systems and have nonlinear behaviors. The results of simulations performed for three different clinical test types indicate that the model is successful in simulating intravenous glucose, oral glucose, and meals containing mainly carbohydrates.
Place, publisher, year, edition, pages
2006. 685-690 p.
, IEEE Conference on Decision and Control, ISSN 0191-2216
IdentifiersURN: urn:nbn:se:kth:diva-50394DOI: 10.1109/CDC.2006.377192ISI: 000252251600071ISBN: 978-1-4244-0170-3OAI: oai:DiVA.org:kth-50394DiVA: diva2:461744
45th IEEE Conference on Decision and Control Location: San Diego, CA Date: DEC 13-15, 2006
QC 201112062011-12-052011-12-052011-12-06Bibliographically approved