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Computational modeling of entorhinal cortex
KTH, Superseded Departments, Numerical Analysis and Computer Science, NADA.ORCID iD: 0000-0003-0281-9450
2000 (English)In: PARAHIPPOCAMPAL REGION: IMPLICATIONS FOR NEUROLOGICAL AND PSYCHIATRIC DISEASES / [ed] Scharfman, HE; Witter, MP; Schwarcz, R, NEW YORK: New York Academy of Sciences, 2000, Vol. 911, 418-446 p.Conference paper, Published paper (Refereed)
Abstract [en]

Computational modeling provides a means for linking the physiological and anatomical characteristics of entorhinal cortex at a cellular level to the functional role of this region in behavior. We have developed detailed simulations of entorhinal cortical neurons and networks, with an emphasis on the role of acetylcholine in entorhinal cortical function. Computational modeling suggests that when acetylcholine levels are high, this sets appropriate dynamics for the storage of stimuli during performance of delayed matching tasks. In particular, acetylcholine activates a calcium-sensitive nonspecific cation current which provides an intrinsic cellular mechanism which could maintain neuronal activity across a delay period. Simulations demonstrate how this phenomena could underlie entorhinal cortex delay activity as described in previous unit recordings. Acetylcholine also induces theta rhythm oscillations which may be appropriate for timing of afferent input to be encoded in hippocampus and for extraction of individual stored sequences from multiple stored sequences. Lower levels of acetylcholine may allow sharp wave dynamics which can reactivate associations encoded in hippocampus and drive the formation of additional traces in hippocampus and entorhinal cortex during consolidation.

Place, publisher, year, edition, pages
NEW YORK: New York Academy of Sciences, 2000. Vol. 911, 418-446 p.
Series
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, ISSN 0077-8923
Keyword [en]
SHORT-TERM-MEMORY, VISUAL RECOGNITION MEMORY, HIPPOCAMPAL THETA-RHYTHM, INFERIOR TEMPORAL CORTEX, LAYER-II NEURONS, SUBTHRESHOLD MEMBRANE RESONANCE, VOLTAGE-DEPENDENT INACTIVATION, PERFORANT PATH PROJECTION, SUSTAINED SODIUM CURRENT, SOURCE DENSITY ANALYSIS
National Category
Neurosciences Bioinformatics (Computational Biology)
Identifiers
URN: urn:nbn:se:kth:diva-51126ISI: 000088609700027PubMedID: 10911889ISBN: 1-57331-263-0 (print)OAI: oai:DiVA.org:kth-51126DiVA: diva2:463441
Conference
Conference on Hippocampal Region - Basic Science and Clinical Implications. BALTIMORE, MARYLAND. SEP 23-26, 1999
Note
QC 20111213Available from: 2011-12-09 Created: 2011-12-09 Last updated: 2011-12-13Bibliographically approved

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Fransén, Erik

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