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Polypeptides having binding affinity for HER2
KTH, School of Biotechnology (BIO), Molecular Biotechnology.ORCID iD: 0000-0002-9282-0174
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2003 (English)Patent (Other (popular science, discussion, etc.))
Abstract [en]

A polypeptide is provided, which has a binding affinity for HER2 and which is related to a domain of staphylococcal protein A (SPA) in that the sequence of the polypeptide corresponds to the sequence of the SPA domain having from 1 to about 20 substitution mutations. Nucleic acid encoding the polypeptide, as well as expression vector and host cell for expressing the nucleic acid, are also provided. Also provided is the use of such a polypeptide as a medicament, and as a targeting agent for directing substances conjugated thereto to cells overexpressing HER2. Methods, and kits for performing the methods, are also provided, which methods and kits rely on the binding of the polypeptide to HER2.

Place, publisher, year, edition, pages
National Category
Biochemistry and Molecular Biology
URN: urn:nbn:se:kth:diva-51325OAI: diva2:463865
EP 1641818 (2008-12-03)

AU 2004253835-B2 (2009-01-29); US 7993650 (2011-08-09); CN 1816563 (2011-02-09); JP 4871126-B2 (2012-02-08)

Available from: 2011-12-12 Created: 2011-12-12 Last updated: 2013-08-07Bibliographically approved

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Ståhl, Stefan
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