Wall shear stress variations and unsteadiness of pulsatile blood-like flows in 90-degree bifurcations
2013 (English)In: Computers in Biology and Medicine, ISSN 0010-4825, E-ISSN 1879-0534, Vol. 43, no 8, 1025-1036 p.Article in journal (Refereed) Published
Complex and slow interaction of different mechanical and biochemical processes in hemodynamics is believed to govern atherogenesis. Over the last decades studies have shown that fluid mechanical factors such as the Wall Shear Stress (WSS) and WSS gradients can play an important role in the pathological changes of the endothelium. This study provides further indications that the effects of fluid mechanical aspects are correlated with the diseased regions of the larger arteries. Unsteady high temporal WSS gradients (TWSSG), a function of the shear-thinning property of the non-Newtonian viscosity, move with the separation bubble. Red Blood Cell (RBC) dilution due to the secondary flows determines the magnitudes of the WSS and TWSSG. The results indicate that the focal nature of the TWSSG may have implications on the response of the endothelium.
Place, publisher, year, edition, pages
2013. Vol. 43, no 8, 1025-1036 p.
Wall shear stress, Wall shear stress gradients, CFD, Blood, Atherosclerosis, Endothelium, Non-Newtonian
Fluid Mechanics and Acoustics
IdentifiersURN: urn:nbn:se:kth:diva-51553DOI: 10.1016/j.compbiomed.2013.05.008ISI: 000321994800007ScopusID: 2-s2.0-84879423922OAI: oai:DiVA.org:kth-51553DiVA: diva2:464519
FunderSwedish Research Council
QC 20130815. Updated from submitted to published.2011-12-132011-12-132013-12-06Bibliographically approved