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Unsteadiness of blood flow in 90-degree bifurcations
KTH, School of Engineering Sciences (SCI), Mechanics.
2011 (English)Licentiate thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Stockholm: KTH Royal Institute of Technology, 2011. , vii, 39 p.
Series
Trita-MEK, ISSN 0348-467X ; 2011:16
Keyword [en]
blood rheology, viscosity, CFD, bifurcations, unsteadiness, wall shear stress
National Category
Fluid Mechanics and Acoustics
Identifiers
URN: urn:nbn:se:kth:diva-51585ISBN: 978-91-7501-194-3 (print)OAI: oai:DiVA.org:kth-51585DiVA: diva2:464771
Presentation
2011-12-08, Sal E3, KTH, Osquars Backe 14, Stockholm, 10:00
Opponent
Supervisors
Note
QC 20111214Available from: 2011-12-14 Created: 2011-12-14Bibliographically approved
List of papers
1. Haemodynamics in a 3D 90-degree bifurcation
Open this publication in new window or tab >>Haemodynamics in a 3D 90-degree bifurcation
2011 (English)In: Proceedings of the ECCOMAS Thematic International Conference on Simulation and Modeling of Biological Flows, Brussels, Belgium, September 21-23, 2011, 2011Conference paper, Published paper (Refereed)
Abstract [en]

The transport behaviour of the haematocrit in the larger arteries is important in defining the variations in viscosityof blood. In this study, a finite volume method is used in order to simulate the blood flow and haematocrit transportthrough a large 3D human-like 90-degree bifurcation. The simulations are carried out to investigate the importance ofexplicitly modelling the non-Newtonian viscosity of blood regarding defining the flow. It is expected to be especiallyimportant in the regions surrounding a bifurcation. The main focus is to compare non-Newtonian to Newtonianbehaviour of the flow through important parameters such as pressure losses, mean viscosity variations and bulktransport properties of haematocrit. The study considers a broad range of physiological and pulsatile flow conditions,and displays the importance of modelling blood flow as a non-Newtonian fluid. The results have a relevant impactregarding the possible discrepencies in important physiological parameters such as wall shear stress (WSS), whencoupling the haematocrit field data back to the viscosity models.

Keyword
Haemodynamics, Blood, Biomechanics, CFD, Bifurcation
National Category
Fluid Mechanics and Acoustics
Identifiers
urn:nbn:se:kth:diva-47809 (URN)
Conference
SIMBIO 2011
Note

QC 20111213

Available from: 2011-12-13 Created: 2011-11-14 Last updated: 2013-12-06Bibliographically approved
2. Wall shear stress variations and unsteadiness of pulsatile blood-like flows in 90-degree bifurcations
Open this publication in new window or tab >>Wall shear stress variations and unsteadiness of pulsatile blood-like flows in 90-degree bifurcations
2013 (English)In: Computers in Biology and Medicine, ISSN 0010-4825, E-ISSN 1879-0534, Vol. 43, no 8, 1025-1036 p.Article in journal (Refereed) Published
Abstract [en]

Complex and slow interaction of different mechanical and biochemical processes in hemodynamics is believed to govern atherogenesis. Over the last decades studies have shown that fluid mechanical factors such as the Wall Shear Stress (WSS) and WSS gradients can play an important role in the pathological changes of the endothelium. This study provides further indications that the effects of fluid mechanical aspects are correlated with the diseased regions of the larger arteries. Unsteady high temporal WSS gradients (TWSSG), a function of the shear-thinning property of the non-Newtonian viscosity, move with the separation bubble. Red Blood Cell (RBC) dilution due to the secondary flows determines the magnitudes of the WSS and TWSSG. The results indicate that the focal nature of the TWSSG may have implications on the response of the endothelium.

Keyword
Wall shear stress, Wall shear stress gradients, CFD, Blood, Atherosclerosis, Endothelium, Non-Newtonian
National Category
Fluid Mechanics and Acoustics
Identifiers
urn:nbn:se:kth:diva-51553 (URN)10.1016/j.compbiomed.2013.05.008 (DOI)000321994800007 ()2-s2.0-84879423922 (Scopus ID)
Funder
Swedish Research Council
Note

QC 20130815. Updated from submitted to published.

Available from: 2011-12-13 Created: 2011-12-13 Last updated: 2017-12-08Bibliographically approved

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Citation style
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