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Nonequilibrium phase transitions in biomolecular signal transduction
KTH, School of Computer Science and Communication (CSC), Theoretical Computer Science, TCS.
2011 (English)In: Physical Review E. Statistical, Nonlinear, and Soft Matter Physics, ISSN 1539-3755, Vol. 84, no 5, 051917- p.Article in journal (Refereed) Published
Abstract [en]

We study a mechanism for reliable switching in biomolecular signal-transduction cascades. Steady bistable states are created by system-size cooperative effects in populations of proteins, in spite of the fact that the phosphorylation-state transitions of any molecule, by means of which the switch is implemented, are highly stochastic. The emergence of switching is a nonequilibrium phase transition in an energetically driven, dissipative system described by a master equation. We use operator and functional integral methods from reaction-diffusion theory to solve for the phase structure, noise spectrum, and escape trajectories and first-passage times of a class of minimal models of switches, showing how all critical properties for switch behavior can be computed within a unified framework.

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2011. Vol. 84, no 5, 051917- p.
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URN: urn:nbn:se:kth:diva-52593DOI: 10.1103/PhysRevE.84.051917ISI: 000297468200003ScopusID: 2-s2.0-83255175543OAI: diva2:467198
ICT - The Next GenerationSwedish Research CouncilICT - The Next Generation
QC 20111219Available from: 2011-12-19 Created: 2011-12-19 Last updated: 2012-06-13Bibliographically approved

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Krishnamurthy, Supriya
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