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Variability of spike firing during theta-coupled replay of memories in a simulated attractor network
KTH, School of Computer Science and Communication (CSC), Computational Biology, CB. (Lansner)
KTH, School of Computer Science and Communication (CSC), Computational Biology, CB. (Lansner)ORCID iD: 0000-0001-6553-823X
KTH, School of Computer Science and Communication (CSC), Computational Biology, CB. (Lansner)ORCID iD: 0000-0002-2358-7815
2012 (English)In: Brain Research, ISSN 0006-8993, E-ISSN 1872-6240, Vol. 1434, 152-161 p.Article in journal (Refereed) Published
Abstract [en]

Simulation work has recently shown that attractor networks can reproduce Poisson-like variability of single cell spiking, with coefficient of variation (Cv(2)) around unity, consistent with cortical data. However, the use of local variability (Lv) measures has revealed area- and layer-specific deviations from Poisson-like firing. In order to test these findings in silico we used a biophysically detailed attractor network model. We show that Lv well above 1, specifically found in superficial cortical layers and prefrontal areas, can indeed be reproduced in such networks and is consistent with periodic replay rather than persistent firing. The memory replay at the theta time scale provides a framework for a multi-item memory storage in the model. This article is part of a Special Issue entitled Neural Coding.

Place, publisher, year, edition, pages
2012. Vol. 1434, 152-161 p.
Keyword [en]
Attractor model, Cortex, Oscillation, Spike statistics, Variability, Working memory
National Category
Bioinformatics (Computational Biology)
Identifiers
URN: urn:nbn:se:kth:diva-52763DOI: 10.1016/j.brainres.2011.07.055ISI: 000301559700015Scopus ID: 2-s2.0-84856624992OAI: oai:DiVA.org:kth-52763DiVA: diva2:467636
Funder
EU, European Research CouncilSwedish e‐Science Research Center
Note

QC 20120416

Available from: 2011-12-19 Created: 2011-12-19 Last updated: 2017-12-08Bibliographically approved

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Herman, Pawel

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